Health Condition 1: P220- Respiratory distress syndrome of newborn
Conditions
Interventions
Intervention1: LISA (Less Invasive Surfactant Administration): Direct laryngoscopy will be performed and surfcath semi stiff LISA catheter will be inserted with black tip mark beyond vocal cord. (Hoba
Sponsors
Government medical college and hospital
Eligibility
Inclusion criteria
Inclusion criteria: Spontaneously breathing preterm neonates between 26 and 35 weeks of gestation who will require surfactant therapy for Respiratory Distress Syndrome.
Exclusion criteria
Exclusion criteria: Babies who had a major congenital anomaly, with hemodynamic instability requiring inotropic support prior to randomization, had suffered severe asphyxia (Apgar score less than 4 at 5 minutes and/or requiring positive pressure ventilation for more than 2 minutes) and those who were already intubated at the time of first surfactant dose.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Need of invasive ventilationTimepoint: Within 72 hours of surfactant administration | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse events (apnea, desaturation, bradycardia) Timepoint: At time of surfactant administration;Death before dischargeTimepoint: Before discharge;Duration of hospitalizationTimepoint: Before discharge;Duration of procedure Timepoint: At time of surfactant administration;Proportion of babies with BPD, ROP (needing treatment), NEC (greater than Stage 2a), IVH (greater than grade2)Timepoint: Before discharge;Requirement of invasive ventilation after 72 hoursTimepoint: Before discharge;Requirement of repeat surfactant dosage Timepoint: Within 24 hours;Total duration of respiratory support & invasive ventilationTimepoint: Before discharge | — |
Countries
India
Contacts
Public ContactDr Palak khera
Government medical college and hospital, chandigarh
Outcome results
None listed