To study and compare the effect of two different modes of ventilation on respiration and oxygenation in patients undergoing laparoscopic surgery in head down position.

Comparative evaluation of volume controlled ventilation versus dual controlled ventilation on respiratory mechanics and oxygenation during laparoscopic surgery in Trendelenburg position. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/07/055840

Enrollment

Registered

2023-07-28

Start date

Unknown

Completion date

Unknown

Last updated

2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: PCS- Health Condition 2: N938- Other specified abnormal uterine and vaginal bleeding

Interventions

Intervention1: Comparative evaluation of volume controlled ventilation versus dual controlled ventilation: In this study we will compare and evaluate the effect of dual controlled ventilation on respi

Eligibility

Inclusion criteria

Inclusion criteria: Patients of either sex, aged 18-65 yrs, American Society of Anesthesiologist Physical Status Classification (ASA-PS) I or II posted for elective laparoscopic surgeries in Trendelenburg position with pneumoperitoneum duration of more than one hour will be included in the study.

Exclusion criteria

Exclusion criteria: 1.Pregnancy 2.Raised intracranial pressure 3. Obesity (Body Mass Index (BMI) > 30kgm-2) 4.Patients of chronic pulmonary disease

Design outcomes

Primary

Measure	Time frame
To evaluate & compare the effect of volume & dual controlled ventilation on airway pressures during laparoscopic surgery in Trendelenburg position. Respiratory and ventilatory parameters: Peak inspiratory pressure (PIP), Plateau pressure (Pplat), mean inspiratory pressure (P mean), dynamic compliance (Cdyn), respiratory rate (RR), exhaled tidal volume Vt, end tidal CO2 (ETCO2) and driving pressure (Dp).Timepoint: The different time points are - T1 - 5 minutes after induction of anesthesia in supine position & before initiation of the pneumoperitoneum. T2 - 5 min after pneumoperitoneum while in Trendelenburg position. T3 - 30 min after pneumoperitoneum while in Trendelenburg position. T4 - 60 min after pneumoperitoneum while in Trendelenburg position.	—

Measure

Time frame

To evaluate & compare the effect of volume & dual controlled ventilation on airway pressures during laparoscopic surgery in Trendelenburg position. Respiratory and ventilatory parameters: Peak inspiratory pressure (PIP), Plateau pressure (Pplat), mean inspiratory pressure (P mean), dynamic compliance (Cdyn), respiratory rate (RR), exhaled tidal volume Vt, end tidal CO2 (ETCO2) and driving pressure (Dp).Timepoint: The different time points are - T1 - 5 minutes after induction of anesthesia in supine position & before initiation of the pneumoperitoneum. T2 - 5 min after pneumoperitoneum while in Trendelenburg position. T3 - 30 min after pneumoperitoneum while in Trendelenburg position. T4 - 60 min after pneumoperitoneum while in Trendelenburg position.

—

Secondary

Measure	Time frame
To compare the effect of volume controlled & dual controlled ventilation on- 1. Lung compliance 2. Oxygenation 3. Hemodynamic parameters Arterial blood gas analysis: arterial partial pressure of oxygen (PaO2), arterial partial pressure of carbon dioxide (PaCO2), pH, & oxygen saturation (SaO2). Oxygenation Index (OI) Hemodynamics: Heart rate (HR), mean arterial pressure (MAP).Timepoint: The different time points are - T1 - 5 minutes after induction of anesthesia in supine position & before initiation of the pneumoperitoneum. T2 - 5 min after pneumoperitoneum while in Trendelenburg position. T3 - 30 min after pneumoperitoneum while in Trendelenburg position. T4 - 60 min after pneumoperitoneum while in Trendelenburg position.	—

Measure

Time frame

To compare the effect of volume controlled & dual controlled ventilation on- 1. Lung compliance 2. Oxygenation 3. Hemodynamic parameters Arterial blood gas analysis: arterial partial pressure of oxygen (PaO2), arterial partial pressure of carbon dioxide (PaCO2), pH, & oxygen saturation (SaO2). Oxygenation Index (OI) Hemodynamics: Heart rate (HR), mean arterial pressure (MAP).Timepoint: The different time points are - T1 - 5 minutes after induction of anesthesia in supine position & before initiation of the pneumoperitoneum. T2 - 5 min after pneumoperitoneum while in Trendelenburg position. T3 - 30 min after pneumoperitoneum while in Trendelenburg position. T4 - 60 min after pneumoperitoneum while in Trendelenburg position.

—

Countries

India

Contacts

Public ContactDr. Ranbir Singh

ESIC Medical College and Hospital Faridabad

rashmi.virmani@gmail.com9654959719

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026