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To compare the hemodynamic parameters like pulse rate, blood pressure and oxygen saturation efficacy of injection etomidate and propofol during endotracheal intubation.

A randomised double blinded comparative study on hemodynamic parameters and adverse effects of intravenous etomidate and intravenous propofol in patients undergoing general anaesthesia with endotracheal tube intubation with controlled ventilation - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/07/055797
Enrollment
80
Registered
2023-07-28
Start date
Unknown
Completion date
Unknown
Last updated
2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Etomidate 0.3mg/kg: Single Dose Intravenous injection Control Intervention1: Propofol 2mg/kg: Single Dose Intravenous injection

Sponsors

Dr Amrutha H A
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients willing to give informed and written consent 2. ASA physical status I & II 3. Patients with body weight 50-70kgs 4. Elective surgeries requiring general anaesthesia with endotracheal tube intubation with controlled ventilation

Exclusion criteria

Exclusion criteria: 1. ASA physical status III and above 2. Patients who have known hypersensitivity to the study drugs 3. Patients who need more than 2 attempts of intubation 4. Patients with history upper respiratory tract infection / eosinophilia. 5. Pregnancy or lactating mothers. 6. History of seizures and/or dystonia 7. Patients who have recently received NSAIDS.

Design outcomes

Primary

MeasureTime frame
-Heart rate -Systolic blood pressure -Diastolic blood pressure -Mean arterial pressure -Oxygen saturation Timepoint: Pre operatively, Pre induction, & at 1st, 3rd, 5th 10th and 30th minute post-induction—

Secondary

MeasureTime frame
-Pain on injection -Post-operative nausea & vomiting -Any abnormal movements visualized Timepoint: Baseline (pre-operative) 1 minute after induction 3 minutes 5 minutes 10 minutes 30 minutes—

Countries

India

Contacts

Public ContactDr Yoganarasimha N

BGS Global Institute of Medical Sciences

yogabmc98@yahoo.co.in9845365348

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026