Oral premedications to prevent shivering during spinal anaesthesia

A simple randomised study for comparison of efficacy of tramadol, tizanidine, clonidine and pregabalin as oral premedications to control intraoperative shivering in patients under spinal anaesthesia - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/07/055780

Enrollment

120

Registered

2023-07-27

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K353- Acute appendicitis with localizedperitonitis Health Condition 2: I839- Asymptomatic varicose veins of lower extremities Health Condition 3: N400- Benign prostatic hyperplasia without lower urinary tract symptoms Health Condition 4: O82- Encounter for cesarean delivery without indication Health Condition 5: M843- Stress fracture Health Condition 6: K409- Unilateral inguinal hernia, without obstruction or gangrene

Interventions

Intervention1: Tramadol: Tab. Tramadol 50mg given orally 90 minutes before subarachnoid block Control Intervention1: Tizanidine: Tab Tizanidine 4mg orally 90 minutes before subarachnoid block Control

Eligibility

Inclusion criteria

Inclusion criteria: Patients of both gender of 18-60 years belonging to ASA I-II grades undergoing elective surgery under subarachnoid block

Exclusion criteria

Exclusion criteria: All ASA III and IV Patients Patients with spinal deformities Local skin infections Coagulation disorders Impaired renal or respirator disorders History of allergy to drugs to be used Cardiovascular or respiratoy disorder BMI >30 kg/m²

Design outcomes

Secondary

Measure	Time frame
Sedative effect of drugsTimepoint: 5 min, 10 min, 15min, 30min, 60 min, 90 min, 120 min, 150 min, 180 min after spinal anaethseia	—

Primary

Measure	Time frame
Intensity of intraoperative shiveringTimepoint: 5min,10min, 15 min, 30min, 45min, 60min, 90min, 120min, 150min, 180 min after subarachnoid block	—

Countries

India

Contacts

Public ContactSneha Abraham

Mysore Medical College and Research Institute, Mysore

drsrinivasvy@gmail.com9448165082

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026