Health Condition 1: 1- Obstetrics
Conditions
Interventions
Intervention1: Mephentermine: When hypotension develops, the first patient will receive 1.2 mg mephentermine IV once and response will be noted for 2 min. The doses for subsequent patients will be dec
Sponsors
University College of Medical Sciences and Guru Teg Bahadur Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1. Healthy mothers with term, uncomplicated, singleton pregnancy undergoing elective caesarean section under spinal anaesthesia 2. Patients who develop hypotension after spinal anaesthesia
Exclusion criteria
Exclusion criteria: 1. History suggestive of maternal complications e.g- pre-eclampsia, cardiovascular disease or cerebrovascular disease 2. Patients with absolute or relative contra-indications for spinal anaesthesia e.g. infection in lumbar area, coagulation abnormalities, history of autonomic neuropathy, spinal deformities, other neurological diseases, hypovolemia due to any cause 3. Patients on monoamine oxidase inhibitors or tricyclic antidepressants 4. History suggestive of mesenteric or peripheral vascular thrombosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| •ED95 of norepinephrine bolus •ED95 of mephentermine bolus •Ratio of ED95 of norepinephrine to ED95 of mephentermine bolus administered for treatment of post-spinal hypotension during elective caesarean section Timepoint: 1 minute after vasopressor bolus | — |
Secondary
| Measure | Time frame |
|---|---|
| •ED50 of norepinephrine bolus •ED50 of mephentermine bolus •Ratio of ED50 of norepinephrine to ED50 of mephentermine bolus administered for treatment of post-spinal hypotension during elective caesarean section •Maternal complicationsTimepoint: 1 minute after vasopressor bolus | — |
Countries
India
Contacts
Public ContactDr Rakesh Kumar
University College of Medical Sciences and Guru Teg Bahardur Hospital
Outcome results
None listed