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Pattern of colonization of gut microbiota in preterm neonates and its association with neonatal sepsis.

Pattern of colonization of gut microbiota in preterm neonates and its association with neonatal sepsis - a one year hospital based prospective observational study. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2023/07/055735
Enrollment
123
Registered
2023-07-26
Start date
Unknown
Completion date
Unknown
Last updated
2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: nil: nil

Sponsors

Jawaharlal Nehru Medical College KLE University Belgaum
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All preterm neonates greater than 28 weeks and less than 37 weeks born at KLEs Dr. Prabhakar Kore Hospital, Belagavi during the study period

Exclusion criteria

Exclusion criteria: 1 Infants with congenital anomalies, cyanotic congenital heart disease 2 Neonates with inborn error of metabolism by clinical signs or lab investigations 3 Neonates with clinically recognizable genetic syndromes 4 Neonates with duration of hospital stay less than 4 days 5 Refusal of consent

Design outcomes

Primary

MeasureTime frame
To study the pattern of colonization of the gut microbiota in preterm neonates (greater than 28 weeks POG & less than 37 weeks POG) & its influence on the incidence & outcome of neonatal sepsisTimepoint: day 1 of life till day of discharge—

Secondary

MeasureTime frame
To assess the risk factors associated with occurrence of Gram-negative bacilli in the gastric aspirate & stool samples of preterm neonates.Timepoint: first gastric aspirate sample within 4 hours of life first stool sample when the baby passes meconium second gastric aspirate & stool sample between day 7 to day 10 of life study will be conducted over a span of 1 year;To find the similarity in antibiotic sensitivity pattern between isolates from the gut & blood samples in preterm neonates with culture positive sepsis & substantiate with molecular analysis.Timepoint: during the course of admission study will be conducted over a span of 1 year—

Countries

India

Contacts

Public ContactDr. Ananya G Rao

Jawaharlal Nehru Medical College, KLE University

niranjanasn@yahoo.com083112444040

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026