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Comparing effect of two doses of tranexamic acid on perioperative blood loss in lumbar spine surgery

Effect of intravenous Tranexamic acid bolus with bolus followed by infusion on perioperative blood loss in adult patients undergoing Multilevel Lumbar Laminectomy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/07/055728
Enrollment
104
Registered
2023-07-26
Start date
Unknown
Completion date
Unknown
Last updated
2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M489- Spondylopathy, unspecified

Interventions

Intervention1: intravenous tranexamic acid bolus dose followed by infusion: intravenous tranexamic acid single bolus dose given 15 minutes before the start of surgery at a dose of 20mg per kg upto a m

Sponsors

Vardhman Mahavir Medical College and Safdarjung Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: patients belonging to physical status grade 1 and 2 according to American society of Anaesthesiologists system

Exclusion criteria

Exclusion criteria: 1.Patients with history of tranexamic acid allergy. 2. Deranged liver or renal functions. 3. Patients with history of significant thromboembolic episodes or coagulopathy.

Design outcomes

Primary

MeasureTime frame
to compare the amount of perioperative blood loss in adult patients undergoing multilevel lumbar laminectomy while using intravenous tranexamic acid bolus followed by infusion with bolus of intravenous tranexamic acidTimepoint: 30 minutes,1hour,1.5 hour, 2 hours, 2.5 hours, 3 hours,24 hours—

Secondary

MeasureTime frame
to compare the need of blood transfusion in both the groupsTimepoint: 24 hours—

Countries

India

Contacts

Public ContactParnika C

Vardhman Mahavir Medical College and Safadarjung Hospital

drmeenakshi86@yahoo.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026