Dexmedetomidine will be compared with Nalbuphine as an add-on drug to the local anaesthetic Ropivacaine for intraperitoneal instillation in patients undergoing Laparoscopic gall bladder removal surgery.

Evaluation of post-operative analgesic effect of intraperitoneal instillation of Ropivacaine with Dexmedetomidine versus Ropivacaine with Nalbuphine in patients undergoing Laparoscopic Cholecystectomy - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/07/055724

Enrollment

100

Registered

2023-07-26

Start date

Unknown

Completion date

Unknown

Last updated

2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Administration of intraperitoneal Ropivacaine with adjuvent drugs.: 50 ml of 0.2% ropivacaine + 1mcg/kg Dexmedetomidine will be compared with 50 ml of 0.2% ropivacaine + 100mcg/kg Nalbu

Eligibility

Inclusion criteria

Inclusion criteria: ASA (American Society of Anesthesiologists) grade I and II Either sex Age group of 18-60 Elective laparoscopic cholecystectomy

Exclusion criteria

Exclusion criteria: Patient who will not give consent. ASA grade III and IV. Allergy to study drug. Second and third degree of heart block. BMI (body mass index) >30kg/m.Pregnancy and lactation. Opioid addiction. Conversion of laparoscopic to open cholecystectomy. Patients on anti-epileptic medication. Drain inserted at surgical site.

Design outcomes

Primary

Measure	Time frame
To evaluate how long the pain relief lasts using intraperitoneal Ropivacaine combined with Nalbuphine as compared to intraperitoneal Ropivacaine combined with DexmedetomidineTimepoint: 24 hours	—

Secondary

Measure	Time frame
Correlation between the use of rescuing analgesics, postoperative shoulder pain, & negative outcomes.Timepoint: 24 hours	—

Countries

India

Contacts

Public ContactDr Shubham Gupta

Maharishi Markandeshwar Medical College and Hospital

gupta.smriti1@gmail.com9418079103

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026