To determine the effectivity of working of oral midodrine tablet in preventing fall in Blood pressure after spinal anesthesia in all lower limb and below abdomen surgeries by giving the tablet before spinal anesthesia

Efficacy of preoperative oral midodrine in preventing hypotension after spinal anesthesia in patients undergoing infraumbilical surgeries. - A placebo controlled study - nil

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/07/055663

Enrollment

120

Registered

2023-07-25

Start date

Unknown

Completion date

Unknown

Last updated

2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Intervention by using MIDODRINE: Patient will be administered midodrine 10mg tablet in powdered form dissolved in 25ml water orally one hour before spinal anesthesia Control Interventio

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade 1 Patients undergoing lower abdomen and lower limb surgeries Patients without local anesthesia toxicity

Exclusion criteria

Exclusion criteria: 1. Patients with history of hypertension, cardiovascular disease, cerebrovascular disease, baseline SBP >140mm Hg before administration of drug 2. Patients with any contraindications to spinal anesthesia 3. History of coagulopathy, pheochromocytoma. 4. Patients on vasoconstrictors. 5. Pregnancy .

Design outcomes

Primary

Measure	Time frame
To study the efficacy of preoperative oral midodrine in prevention of hypotension after spinal anesthesia in patients undergoing lower abdominal & lower limb surgeries.Timepoint: Hemodynamic variables comprising SBP,DBP,MAP and HR will be recorded at 2,5, 10, 15, 20, 25, 30, 45, and 60 minutes after spinal anesthesia, every 15 mins until the end of the surgery.	—

Secondary

Measure	Time frame
To assess hemodynamic parameters like SBP,DBP, MAP, HR for 24 hours after administration of MIDODRINE. To asses the number of doses of mephentermine used.Timepoint: 12 hours	—

Countries

India

Contacts

Public ContactRakshitha R

Jawaharlal Nehru medical college and hospital

Mcpatil52@rediffmail.com9743110637

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026