Low dose protamine for reversal of heparin anticoagulation in cardiac surgery

Effectiveness of low-dose protamine regimes on reversal of heparin anticoagulation during off pump coronary artery bypass grafting (OPCABG) surgery. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/07/055633

Enrollment

80

Registered

2023-07-25

Start date

Unknown

Completion date

Unknown

Last updated

2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I251- Atherosclerotic heart disease of native coronary artery

Interventions

Intervention1: Protamine: Protamine dose 2/3rd of the total dose of heparin Control Intervention1: Protamine: Protamine dose 1/2 of the total dose of heparin.

Sponsors

NETAJI SUBHASH CHANDRA BOSE MEDICAL COLLEGE JABALPUR

Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: NYHA CLASS I TO III LVEF > 35% CORONARY ARTERY BYPASS GRAFT < 5

Exclusion criteria

Exclusion criteria: PREOPERATIVE CONGENITAL/ ACQUIRED DISORDERS OF HAEMOSTASIS PATIENT NEEDED IABP SUPPORT ACS

Design outcomes

Secondary

Measure	Time frame
To compare effectiveness of low dose regime of protamine 2/3rd & 1/2 of the total dose of heparin in OPCABG & to ascess the extent of restoration of coagulation after low dose regimes of protamineTimepoint: 12 months	—

Primary

Measure	Time frame
To determine the lowest optimal dose of protamine needed for effective reversal of heparin anticoagulation.Timepoint: 8 weeks,16weeks,24 weeks	—

Countries

India

Contacts

Public ContactVISHWANATH MOHIRE

NETAJI SUBHASH CHANDRA BOSE MEDICAL COLLEGE JABALPUR

vbm201a@gmail.com8744090856

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026