Increasing breathing in (inspiratory) time while breathing through the ventilator during the surgery and seeing its effect in reducing lung collapse after surgery by doing a lung ultrasound at the end of surgery.

Effect of I:E ratio optimisation and prolonged end inspiratory pause on post-operative lung atelectasis and pulmonary complications in adult patients undergoing major open abdominal surgery: A randomised controlled trial.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/07/055532

Enrollment

Registered

2023-07-24

Start date

Unknown

Completion date

Unknown

Last updated

2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Low PEEP and optimised I: E ratio: The I:E will be gradually increased from 1:2 by decreasing expiratory fraction by 0.2, till a ratio of 1:1 is achieved. An end inspiratory pause will

Eligibility

Inclusion criteria

Inclusion criteria: Adults undergoing major open abdominal surgery under general anesthesia

Exclusion criteria

Exclusion criteria: a) Patients refusal to participate in the study b) Known COPD or other chronic lung diseases c) Patients undergoing esophageal surgery, hepatic resection d) Known deformity of chest wall or thoracic spine e) Pre-existing significant cardiac diseases. f) Patients with history of previous thoracic surgery, pneumothorax. g) BMI > 30 kg/m2, h) People undergoing emergency laparotomy.

Design outcomes

Primary

Measure	Time frame
Difference in modified lung USG score between two groups.Timepoint: At the end of surgery.	—

Secondary

Measure	Time frame
To compare oxygenation parameters ( P/F calculated as ratio of arterial pO2,P from ABG and fiO2, F).Timepoint: at 2 hours after induction and at the end of surgery.;To compare shunt fraction.Timepoint: at 2 hours after induction and at the end of surgery.;Difference in modified lung USG score.Timepoint: on postoperative day 1 between two groups.;To compare pulmonary mechanics: 1) Static compliance 2) Mean airway pressure 3) Peak airway pressure 4) Plateau airway pressureTimepoint: Average of all values measured hourly after induction, respectively. ;To compare hemodynamic parameters 1) Mean arterial pressure Timepoint: Average of all values measured hourly after induction.;2) Need for vasopressorsTimepoint: Average of VIS, vasomotor inotrope score, measured hourly after induction.;To compare the number of patients requiring supplemental oxygen to maintain SaO2 more than 94%Timepoint: at 30 minutes after extubation in patients who are extubated on table.;Melbourne group scoreTimepoint: on day 3 and day 5.;To compare 1) Length of postoperative ICU stay 2) Length of hospital stayTimepoint: After surgery	—

Measure

Time frame

To compare oxygenation parameters ( P/F calculated as ratio of arterial pO2,P from ABG and fiO2, F).Timepoint: at 2 hours after induction and at the end of surgery.;To compare shunt fraction.Timepoint: at 2 hours after induction and at the end of surgery.;Difference in modified lung USG score.Timepoint: on postoperative day 1 between two groups.;To compare pulmonary mechanics: 1) Static compliance 2) Mean airway pressure 3) Peak airway pressure 4) Plateau airway pressureTimepoint: Average of all values measured hourly after induction, respectively. ;To compare hemodynamic parameters 1) Mean arterial pressure Timepoint: Average of all values measured hourly after induction.;2) Need for vasopressorsTimepoint: Average of VIS, vasomotor inotrope score, measured hourly after induction.;To compare the number of patients requiring supplemental oxygen to maintain SaO2 more than 94%Timepoint: at 30 minutes after extubation in patients who are extubated on table.;Melbourne group scoreTimepoint: on day 3 and day 5.;To compare 1) Length of postoperative ICU stay 2) Length of hospital stayTimepoint: After surgery

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Countries

India

Contacts

Public ContactAmisha Maroo

All India Institute of Medical Sciences

priyankar.k.datta@gmail.com9830771756

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026