To compare effect of nor epinephrine and phenylephrine in cases of blood pressure decrease in pregnant women undergoing emergency cesarean section under spinal anaesthesia.

To compare bolus doses of nor epinephrine and phenylephrine for treatment of maternal hypotension undergoing emergency lower segment cesarean section under subarachnoid block : A Randomized Clinical Study. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/07/055528

Enrollment

210

Registered

2023-07-24

Start date

Unknown

Completion date

Unknown

Last updated

2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 1- Obstetrics

Interventions

Intervention1: Not Epinephrine: 4 micrograms as intravenous bolus from administration of sub arachnoid block to end of surgery, if required. Control Intervention1: Phenylepherine: 50 micrograms as int

Eligibility

Inclusion criteria

Inclusion criteria: Those parturients who will develop hypotension after subarachnoid block, with systolic blood pressure being <20% of the baseline value will be included in the study.

Exclusion criteria

Exclusion criteria: Parturients with:- 1.Fetal Abnormality. 2.Preexisting or Pregnancy Induced Hypertension. 3.Known Cardiovascular or Cerebrovascular Disease. 4.Thrombocytopenia. 5.Coagulopathy or any medical contraindication to spinal anesthesia. 6.Weight 100kg. 7.Height 180 cm. 8.Parturient using monoamine oxidase inhibitors or tricyclic anti-depressants. 9.Parturient allergic to study drug. 10.Refusal of informed consent.

Design outcomes

Primary

Measure	Time frame
1.Haemodynamic Changes: Blood pressure & HR will be monitored every 2 mins till 10 min, & thereafter every 5 min till the end of surgery. Incidence of hypotension, bradycardia, tachycardia, hypertension will be noted. 2.No. of boluses of vasopressor agents given intraoperatively will be noted. Timepoint: From administration of sub arachnoid block to end of surgery.	—

Secondary

Measure	Time frame
1.Fetal Outcome: A paediatrician who will not be aware of the vasopressor used will note: a) APGAR SCORE:- at 1 min & 5 mins. b) Fetal Acidosis:- Umbilical arterial sample will be collected at the time of birth to analyse pH. Fetal acidosis will be defined as pH less than 7. 2.Complications if any: Incidence of dizziness, nausea, vomiting or shivering due to maternal hypotension will also be noted. Timepoint: From administration of sub arachnoid block to end of surgery.	—

Measure

Time frame

1.Fetal Outcome: A paediatrician who will not be aware of the vasopressor used will note: a) APGAR SCORE:- at 1 min & 5 mins. b) Fetal Acidosis:- Umbilical arterial sample will be collected at the time of birth to analyse pH. Fetal acidosis will be defined as pH less than 7. 2.Complications if any: Incidence of dizziness, nausea, vomiting or shivering due to maternal hypotension will also be noted. Timepoint: From administration of sub arachnoid block to end of surgery.

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Countries

India

Contacts

Public ContactDr Vibha Mehta

Maharaja Agarsen Medical College,Agroha,Hisar,Haryana

drvibhamehta1@gmail.com9466088221

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026