Gingival crevicular fluid levels of NLRP3 before and after endodontic treatment

Assessment of Endodontic treatment outcome based on Gingival crevicular fluid levels of NLRP3 & pain score in symptomatic irreversible pulpitis- A cross-sectional study - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/07/055526

Enrollment

Registered

2023-07-24

Start date

Unknown

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: GROUP 2 GCF sample collection before and after root canal therapy: SYMPTOMATIC IRREVERSIBLE PULPITIS Record of pre-operative pain score will be done by using HP VAS GCF sample collecti

Eligibility

Inclusion criteria

Inclusion criteria: Patients diagnosed with symptomatic irreversible pulpitis as per the clinical and pulp sensibility tests and HP VAS score more than 54 Patients no relevant medical history or absence of any systemic conditions Non-smokers

Exclusion criteria

Exclusion criteria: Patients with periodontitis Patients with multiple carious teeth Teeth with periapical radiolucencies and tender to percussion

Design outcomes

Primary

Measure	Time frame
NLRP3 levels in GCF may be increase & hence detectable in patients with Symptomatic Irreversible Pulpitis but will reduce after endodontic treatmentTimepoint: one year	—

Secondary

Measure	Time frame
Pain levels may be increase & hence detectable in patients with Symptomatic Irreversible Pulpitis but will reduce after endodontic treatmentTimepoint: one year	—

Countries

India

Contacts

Public ContactDax Abraham

Manav Rachna Dental College

daxabraham.mrdc@mrei.ac.in9910433111

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026