Comparison of the effect Two Toothpastes in Orthodontic Patients to reduce plaque accumulation in the mouth and to reduce the antioxidant levels in the saliva.

Anti-plaque Efficacy of Two Commercially Available Dentifrices Usage on the Clinical and Biochemical Profile in Orthodontic Patients. A randomised controlled clinical trial. - NIL

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/07/055494

Enrollment

Registered

2023-07-21

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K051- Chronic gingivitis

Interventions

Intervention1: Oral Prophylaxis: Scaling prior to Orthodontic Therapy Control Intervention1: Enzycal 950: Agent is in form of a toothpaste. Around 2cm of paste will be applied on the toothbrush and b

Eligibility

Inclusion criteria

Inclusion criteria: 1. Presence of minimum 24 functional teeth 2. Patients with moderate to severe form of chronic generalized gingivitis.

Exclusion criteria

Exclusion criteria: 1. Advanced periodontal diseases and caries. 2. Any prescribed antibiotic therapy coverage for the last 6 months 3. Systemic diseases

Design outcomes

Primary

Measure	Time frame
The Primary outcome will be the reduction in plaque index, gingival index, bleeding on probing which will reflect the antimicrobial effect of the experimental dentifrices.Timepoint: 6,12,24 weeks	—

Secondary

Measure	Time frame
To detect the levels of AOPP, TAC & Myeloperoxidase in saliva at baseline and at 24 weeks, following use of experimental dentifrices.Timepoint: 24 weeks	—

Countries

India

Contacts

Public ContactJothi M Varghese

Manipal College of Dental Sciences Manipal Karnataka

jothimv@gmail.com9845208532

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 20, 2026