Effectiveness of Injections into the knee joint like Platelet Rich Plasma with (Hyaluronic Acid) Gel in comparison with Botulinum Toxin type A (Derived from Bacteria) with (Hyaluronic Acid) Gel in reducing Knee pain and improving function of Knee in cases of degenerative disease of Knee.

Effectiveness of Intra- Articular Platelet Rich Plasma with Hyaluronic Acid in comparison with Intra- Articular Botulinum Toxin Type-A with Hyaluronic Acid in improving pain and functional limitation in Osteoarthritis of Knee: A Randomized Clinical Trial. - NIL

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/07/055477

Enrollment

Registered

2023-07-21

Start date

Unknown

Completion date

Unknown

Last updated

2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M170- Bilateral primary osteoarthritis of knee

Interventions

Intervention1: Botulinum Toxin type A and Hyaluronic Acid: Route of administration: Knee Intra- articular Dose: 100 units of Botulinum Toxin type A and 60mg of Hyaluronic Acid. Frequency: Once. Durati

Eligibility

Inclusion criteria

Inclusion criteria: 1.Bilateral Knee Osteoarthritis Grade 3 and 4. 2.Knee pain > 3 months. 3.Morning stiffness < 30 minutes.

Exclusion criteria

Exclusion criteria: 1.Patient’s unwillingness to participate. 2.History of other diseases affecting knee joint like Rheumatoid Arthritis, Gout, Neuromuscular diseases. 3.Previous intra-articular injections. 4.History of knee joint surgery. 5.Acute Trauma. 6.Contraindications to intra-articular injection e.g., sepsis, intra-articular infections, intra-articular fracture, or uncontrolled coagulopathy.

Design outcomes

Primary

Measure	Time frame
1.To evaluate the efficacy of intra- articular Platelet rich plasma with Hyaluronic Acid (PRP with HA) in comparison with intra- articular Botulinum Toxin A with Hyaluronic Acid on knee pain. 2.To evaluate the effect of intra- articular PRP with HA in comparison with intra- articular Botulinum Toxin A with Hyaluronic Acid on functional limitation of Knee. 3.To assess the effect of patient factors post procedure, on knee pain & functional limitation .Timepoint: Pre- Procedural, Immediate post procedure, 2weeks, 4 weeks, 12 weeks and 24 weeks.	—

Measure

Time frame

1.To evaluate the efficacy of intra- articular Platelet rich plasma with Hyaluronic Acid (PRP with HA) in comparison with intra- articular Botulinum Toxin A with Hyaluronic Acid on knee pain. 2.To evaluate the effect of intra- articular PRP with HA in comparison with intra- articular Botulinum Toxin A with Hyaluronic Acid on functional limitation of Knee. 3.To assess the effect of patient factors post procedure, on knee pain & functional limitation .Timepoint: Pre- Procedural, Immediate post procedure, 2weeks, 4 weeks, 12 weeks and 24 weeks.

—

Secondary

Measure	Time frame
To assess the effect of patient factors post procedure, on knee pain & functional limitation .Timepoint: Baseline, At the end of 24 weeks.	—

Countries

India

Contacts

Public ContactDr Shubha V Hegde

Alleviate Pain Management Hospital

khaja.javed.khan@gmail.com9008497791

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026