Health Condition 1: M472- Other spondylosis with radiculopathy
Conditions
Interventions
Intervention1: Balanced anaesthesia: The provision of general anaesthesia through a combination of intravenous anaesthesia and inhalation anaesthesia is known as balanced anaesthesia.
Total Duration
Sponsors
Roshika Gopalakrishnan
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 65 years old of either gender. 2. American society of Anaesthesiologists physical status (ASA) 1 & 2 patients 3. Patients undergoing elective minimally invasive lumbar spine surgery with estimated duration of 2-4 hours.
Exclusion criteria
Exclusion criteria: 1. Refusal to consent for proposed study. 2. Conversion of minimally invasive spine surgery to open spine surgery 3. Benzodiazepine, Opioids, Corticosteroids, β-blocker, Calcium Channel Blockers, gabapentinoids use within 48 hours. 4. Hypersensitivity to any of the study drugs 5. Chronic or Acute Inflammatory conditions. 6. Endocrine / Hepatic / renal / cardiovascular diseases 7. Pregnant or lactating mothers, malignancy 8. BMI > 30kg/m2
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the surgical stress response in terms of cortisol, glucose, lactate & total leucocyte levels between Total Intravenous Anaesthesia & Balanced Anaesthesia in patients undergoing minimally invasive lumbar spine surgery Timepoint: 1.Baseline sampling for cortisol, glucose, lactate, total leucocyte count will be done at the time of drawing blood for routine preoperative investigations 1 day prior to surgery.. 2.Blood sampling for the assessment of cortisol , glucose, lactate, total leucocyte count will be done postoperatively 2 hours after the surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| To analyze the incidence of Post operative nausea & vomiting between the groups.Timepoint: From extubation till 2 hours post surgery;To compare the intraoperative fentanyl usage between the two groups.Timepoint: From induction of anaesthesia till extubation;To compare the intraoperative hemodynamic variables between the two groups. Timepoint: Hemodynamic parameters (Heart rate, Systolic & diastolic blood pressure, mean arterial pressure, oxygen saturation, EtCO2) will be monitored at baseline, post induction, post intubation every 5 mins for the first half an hour, every 15 minutes till the end of procedure and 5 mins post extubation. | — |
Countries
India
Contacts
Public ContactDR Geetha L
MS Ramaiah Medical College and Hospitals
Outcome results
None listed