Efficacy of Bromelain in Post Endodontic Pain

Comparative Evaluation of Bromelain And Diclofenac In The Management Of Postoperative Pain And Quality Of Life Following Root Canal Therapy - A Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/07/055392

Enrollment

100

Registered

2023-07-20

Start date

Unknown

Completion date

Unknown

Last updated

2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: capsule Bromelain 200 mg - twice a day for three days, intra oral administration.: Bromelain is given to the study group Control Intervention1: Tablet Diclofenac 50mg - twice a day- int

Eligibility

Inclusion criteria

Inclusion criteria: Teeth diagnosed with symptomatic irreversible pulpitis with or without apical periodontitis (acute or chronic) Primary root canal treatment cases Fully matured mandibular molars Systemically healthy patients Teeth with enough crown structure for adequate isolation

Exclusion criteria

Exclusion criteria: Patients on anticoagulant therapy, those with a history of peptic ulcer disease/GI bleeding, those allergic to bromelain or diclofenac, who used any analgesics or antibiotic drugs within two weeks of the study. Patients with chronic systemic disease

Design outcomes

Primary

Measure	Time frame
1. Visual Analogue Scale for post-operative pain 2. Post operative Quality of life scoreTimepoint: 6,12,24,48,72 hours and 7 days	—

Secondary

Measure	Time frame
1. Adverse Effects 2. Patients needing rescue drug for painTimepoint: 6,12,24,48,72 hours and 7 days	—

Countries

India

Contacts

Public ContactAnirudhan Subha

Sri Ramakrishna Dental College and Hospital

subhaanirudhan1@gmail.com9500412805

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026