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A comparative study of effect of intravenous labetalol, esmolol and lignocaine in attenuation of sympathomimetic changes to laryngoscopy and endotracheal intubation

A Comparative Study of Effect of Intravenous Labetalol,Esmolol and Lignocaine in Attenuation of Sympathomimetic Changes to Laryngoscopy and Endotracheal Intubation â?? A Prospective Double Blind Randomised Control Study - NIL

Status
Active, not recruiting
Phases
Phase 1Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/07/055301
Enrollment
120
Registered
2023-07-17
Start date
Unknown
Completion date
Unknown
Last updated
2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Inj.Labetalol 0.2mg/kg given over 30 seconds: IV LABETALOL 0.2mg/ kg given over 30 seconds, 5min prior to laryngoscopy and endotracheal intubation.Parameters like Heart Rate(HR), Systol

Sponsors

DrRADHA
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients of ASA I and ASA II category undergoing general anaesthesia with endotracheal intubation.

Exclusion criteria

Exclusion criteria: Patients of ASA grade III or more. Ischemic heart disease. Hypertension. Anticipated difficult airway.

Design outcomes

Primary

MeasureTime frame
To compare haemodynamic changes across all 3 groups during & immediately after laryngoscopy & endotracheal intubation.Timepoint: 2 years—

Secondary

MeasureTime frame
To compare the clinically significant adverse effects like bradycardia, hypotension requiring treatment. Definitions : Heart rate less than 50bpm is defined as bradycardia requiring treatment. Hypotension requiring treatment is defined as MAP less than 60 mmHgTimepoint: 2 YEARS—

Countries

India

Contacts

Public ContactDrRADHA

SDM COLLEGE OF MEDICAL SCIENCES AND HOSPITAL

pavandhulkhed1984@gmail.com8150885678

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026