A comparison of the effects of ketamine versus propofol (sedation) on blood flow to the brain in patients of traumtic brain injury

A prospective randomised, double-blinded study on the cerebral haemodynamic effects of ketamine versus propofol sedation in patients with severe traumatic brain injury admitted in trauma intensive care - NIL

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/07/055227

Enrollment

Registered

2023-07-14

Start date

Unknown

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G936- Cerebral edema

Interventions

Intervention1: Ketamine sedation: Ketamine at a dose of 1-5mg/kg/hr infusion to patients of moderate to severe traumatic brain injury requiring mechanical ventilation Control Intervention1: Propofol s

Eligibility

Inclusion criteria

Inclusion criteria: 1.ASA physical status I-III 2.Marshall CT score more than 2

Exclusion criteria

Exclusion criteria: a) Patients with thrombocytopenia (platelet count less than 1 lac/mm3) or coagulopathy (INR >1.5) b) Polytrauma with Injury severity Score more than 15

Design outcomes

Primary

Measure	Time frame
Cerebral Perfusion Pressure following initiation of sedation regimen till 48 hours of mechanical ventilation Timepoint: Cerebral Perfusion Pressure following sedation regimen will be assessed hourly for the first 12 hours, 2 hourly for the next 12 hours and 4 hourly till 48 hours of mechanical ventilation.	—

Secondary

Measure	Time frame
1. Time for resolution of raised ICPTimepoint: 72 hours;2. GOS-E at 3 months follow upTimepoint: 3 months after discharge	—

Countries

India

Contacts

Public ContactRevathi Nair

Postgraduate Institute of medical Education and Research, Chandigarh

kajalteji@gmail.com9814528468

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026