â??Comparison of single and multidose pharmacokinetics of Posaconazole eye dropsâ??

â??Comparative evaluation of single and multidose ocular kinetics of topical posaconazole in humansâ??

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/07/055226

Enrollment

Registered

2023-07-14

Start date

Unknown

Completion date

Unknown

Last updated

2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H251- Age-related nuclear cataract

Interventions

Intervention1: Topical posaconazole eyedrop 1 % instillation for pharmacokinetics analysis : Patients and healthy volunteers will receive single dose and multidose (1 hourly & 2 hourly, total 5 doses)

Eligibility

Inclusion criteria

Inclusion criteria: Patients and healthy volunteers consent to participate in this study

Exclusion criteria

Exclusion criteria: patients less than 18 years of age not willing to participate in this study patients with complicated cataract

Design outcomes

Secondary

Measure	Time frame
To compare the ocular penetration and aqueous concentration of single dose and multi dose application of 1% concentration of topical Posaconazole eye drop.Timepoint: after 1 hour of last drop instillation	—

Primary

Measure	Time frame
The primary objective of this study will be to evaluate the pharmacokinetics of single and multiple doses of topical Posaconazole eye drop in human eye.Timepoint: aqueous and tear fluid analysis after 1 hour of last drop of posaconazole instillation	—

Countries

India

Contacts

Public ContactM Vanathi

All India Institute of Medical Sciences, New delhi

mvanathirpc@gmail.com9400977217

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026