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Role of Splenic stiffness measurement to predict High risk esophageal varices in cirrhosis

Role of Splenic Stiffness Measurement by a Novel Spleen dedicated Transient Elastography in predicting High Risk Esophageal Varices in Patients with Liver Cirrhosis â?? An Observational Cross-sectional Study.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2023/07/055222
Enrollment
138
Registered
2023-07-14
Start date
Unknown
Completion date
Unknown
Last updated
2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K702- Alcoholic fibrosis and sclerosis of liver Health Condition 2: K754- Autoimmune hepatitis Health Condition 3: K721- Chronic hepatic failure Health Condition 4: K740- Hepatic fibrosis Health Condition 5: K746- Other and unspecified cirrhosis ofliver Health Condition 6: K766- Portal hypertension Health Condition 7: K717- Toxic liver disease with fibrosisand cirrhosis of liver

Interventions

None listed

Sponsors

Dr Manas Kumar Panigrahi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age > 18 years 2. Features of cirrhosis â?? based on clinical, biochemical, radiological, and transient elastography findings and liver biopsy when appropriate. 3. Willing to give informed consent for participation in the study

Exclusion criteria

Exclusion criteria: 1. Grade II/III ascites at time of evaluation 2. Non-cirrhotic portal hypertension â?? Extrahepatic Portal vein obstruction (EHPVO), Non-cirrhotic portal fibrosis (NCPF) 3. History of Endoscopic variceal ligation 4. Currently using beta-blocker for prophylaxis 5. Portal vein thrombosis 6. Patients having liver space-occupying lesion on imaging 7. History of variceal hemorrhage in last 4 weeks 8. History of liver transplantation 9. History of a transjugular intrahepatic portosystemic shunt (TIPS) 10. History of splenectomy 11. Presence of heart failure 12. Pregnancy 13. Patients are not willing to give informed consent.

Design outcomes

Primary

MeasureTime frame
To determine the diagnostic accuracy of splenic stiffness measurement using a novel spleen dedicated transient elastography in predicting high risk esophageal varices in patients with liver cirrhosis.Timepoint: All the parameters will be assessed at baseline after patient enrolment—

Secondary

MeasureTime frame
To compare the diagnostic accuracy of splenic stiffness measurement with Baveno VI consensus criteria in identifying low-risk group where screening endoscopy for variceal assessment can be avoided.Timepoint: December 2023—

Countries

India

Contacts

Public ContactJain Harsh Prakash

AIIMS, Bhubaneswar

medgast_manas@aiimsbhubaneswar.edu.in9861278332

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026