A study evaluating the effect of four commonly prescribed pain killers on dental diagnostic tests

A prospective randomized controlled double blinded clinical trial evaluating the effect of four commonly prescribed analgesics on pulpal sensibility tests - Nil

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/07/055176

Enrollment

Registered

2023-07-13

Start date

Unknown

Completion date

Unknown

Last updated

2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: Ketorolac tromethamine, Ibuprofen, Acetaminophen, Diclofenac : Ketorolac tromethamine (10mg), Ibuprofen (400mg), Acetaminophen (650mg), Diclofenac (100mg) as per randomization will be

Eligibility

Inclusion criteria

Inclusion criteria: Adult males & females between 18-65 years of age with moderate to severe pain due to symptomatic irreversible pulpitis (SIP) will be selected for this study. The subjects should not have used any analgesic or anti-depressant in past 6 hrs.

Exclusion criteria

Exclusion criteria: 1) If the subject has consumed an analgesic or an anti-depressant less than six hours before presentation to the dental office will be excluded. 2) A selected candidate who refuses to sign the informed consent to be a part of this study shall not be included in the study. 3) Any subject who is allergic to any of the drugs being studied will be excluded from the study or if for medical reasons cannot be prescribed NSAIDs will also not be included. 4) If the tooth with SIP does not respond to cold test or If the tooth has periapical disease, it will be excluded from the study. 5) Participants with American Society of Anesthesiology (ASA) physical status > 1 will be excluded.

Design outcomes

Primary

Measure	Time frame
The drugs under study will surely effect the pain perception of the patient & hence cause modification in the pulp sensibility reflected by the VAS scale for pain. This will help us reach a conclusion which NSAID should be given prior to treatment in cases of symptomatic irreversible pulpits, a highly painful situation so that the patient has a pleasant & pain free experience during the treatment of a painful tooth.Timepoint: It involves data at 0 minutes, 20 minutes, 40 minutes & 60 minutes & would be a single sitting procedure.	—

Measure

Time frame

The drugs under study will surely effect the pain perception of the patient & hence cause modification in the pulp sensibility reflected by the VAS scale for pain. This will help us reach a conclusion which NSAID should be given prior to treatment in cases of symptomatic irreversible pulpits, a highly painful situation so that the patient has a pleasant & pain free experience during the treatment of a painful tooth.Timepoint: It involves data at 0 minutes, 20 minutes, 40 minutes & 60 minutes & would be a single sitting procedure.

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Secondary

Measure	Time frame
NoneTimepoint: None	—

Countries

India

Contacts

Public ContactDr Rajat Kapur

National Dental College and Hospital

hodconsendondch@gmail.com9915311355

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026