Health Condition 1: K040- Pulpitis
Conditions
Interventions
Intervention1: Nil: Nil
Control Intervention1: GROUP 1 (CONTROL): Group 1 will constitute healthy individuals with no evidence of caries and systemic diseases
Control Intervention2: GROUP 2: Group 2 w
Sponsors
Mudit Sharma
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria for group 1 1.Patients aged 18-40 years of age 2.Patients with no relevant medical history or absence of any systemic conditions 3.Non-smokers 4.OHI index of 0 and Russel’s Periodontal index (not >0.9) Inclusion criteria for group II,III,IV 1.Patients with mandibular molars diagnosed with symptomatic reversible pulpitis, symptomatic irreversible pulpitis and pulpal necrosis respectively diagnosed according to AAE guidelines 2013 2.Patients with no relevant medical history or absence of any systemic conditions
Exclusion criteria
Exclusion criteria: 1.Use of opioid analgesics or antibiotics 48 hours prior to specimen collection 2.Narcotic drug use - Habit of smoking or tobacco chewing 3.Having conditions that effects saliva flow such as xerostomia, radiotherapy, etc. 4.Having a systemic disease 5.Being pregnant or breastfeeding - 6.Having an infectious disease known to be transmitted by saliva. 7.having Russel’s Periodontal index >0.9 8.Inability to understand the content of the informed consent form
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare salivary TNF-a levels in normal, reversible pulpitis, irreversible pulpitis & necrotic pulpal tissues by using sandwich ELISA techniqueTimepoint: 6-12 months for sample collection & evaluation of samples by ELISA | — |
Secondary
| Measure | Time frame |
|---|---|
| To estimate salivary TNF-a levels in normal pulpal tissues (caries free individuals) Timepoint: 6-12 months for sample collection & evaluation of samples by ELISA;To estimate salivary TNF-a levels in patients diagnosed with pulpal necrosis.Timepoint: 6-12 months for sample collection & evaluation of samples by ELISA;To estimate salivary TNF-a levels in patients diagnosed with reversible pulpitisTimepoint: 6-12 months for sample collection & evaluation of samples by ELISA;To estimate salivary TNF-a levels in patients diagnosed with symptomatic irreversible pulpitisTimepoint: 6-12 months for sample collection & evaluation of samples by ELISA | — |
Countries
India
Contacts
Public ContactMudit Sharma
Manav Rachna Dental College,faridabad
Outcome results
None listed