A study to assess the competency of drugs between ondansetron and aprepitant in preventing patient with post surgical nausea and vomiting.

comparative study of the effect of aprepitant vs ondansetron in preventing post operative nausea and vomiting in laparoscopic surgery a prospective, randomized double blind control study

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/07/055093

Enrollment

114

Registered

2023-07-11

Start date

Unknown

Completion date

Unknown

Last updated

2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K352- Acute appendicitis with generalized peritonitis Health Condition 2: K800- Calculus of gallbladder with acutecholecystitis Health Condition 3: N800- Endometriosis of uterus

Interventions

Intervention1: Ondansetron: 4mg end of surgery intravenous Control Intervention1: Aprepitant: 80mg one hour before surgery orally

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1 and 2 UNDERGOING LAPAROSCOPIC SURGERY UNDER GA LESS THAN 4 HOUR

Exclusion criteria

Exclusion criteria: PATIENT REFUSAL ASA 3 AND 4 ON ANY OTHER DRUG CAUSING EMESIS KNOWN TO CAUSE ALLERGY TO ABOVE DRUGS PATIENT WHO IS ALREADY ON ANTI EMETIC DRUGS

Design outcomes

Primary

Measure	Time frame
THIS STUDY HELP US TO FIND OUT THE EFFECT OF APREPITANT VERSUS ONDANSETRON IN PREVENTING POST OPERATIVE NASUEA AND VOMITING IN LAPAROSCOPIC SURGERIESTimepoint: baseline, 6 hours, 24 hours and 48 hours.	—

Secondary

Measure	Time frame
TIME DURATION NEEDED FOR THE USAGE OF RESCUE ANTIEMETICTimepoint: baseline, 6 hours, 24 hours & 48 hours.	—

Countries

India

Contacts

Public ContactDr Sathya Priya P

SRI MUTHUKUMARAN MEDICAL COLLEGE HOSPITAL AND RESEARCH INSTITUTE

vishy.scorpio86@gmail.com9176424387

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026