Comparing the safety and efficient drug among palonosetron ondansetron and granisetron to prevent vomiting after laparoscopic surgeries.

A comparative study on efficacy of intravenous palonosetron ondansetron and granisetron as a prophylaxis for prevention of post operative nausea and vomiting after laproscopic surgeries - Not applicable

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/07/054961

Enrollment

180

Registered

2023-07-07

Start date

Unknown

Completion date

Unknown

Last updated

2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Z768- Persons encountering health services in other specified circumstances

Interventions

Intervention1: PALONOSETRON: PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING AFTER LAPAROSCOPIC SURGERIES DOSE 0.075 micrograms post operative 24 hours Intervention2: GRANISETRON: PREVENTION OF POSTO

Eligibility

Inclusion criteria

Inclusion criteria: Patients who give valid inform consent and willing to participate in the study ASA grade I/II patients Age group of 18 to 60 years scheduled to undergo elective laparoscopic surgeries, under general anaesthesia.

Exclusion criteria

Exclusion criteria: Patient refusing to participate in the study Any contraindication to the use of drug ASA III or more, Emergency procedure Pregnant and lactating patients Patients with history of motion sickness Patients on steroid therapy, antiemetics or on treatment with other medication known to produce nausea and vomiting .

Design outcomes

Primary

Measure	Time frame
To compare the efficacy of a single dose of palonosetron versus ondansetron versus granisetron for the prevention of postoperative nausea & vomiting after laparoscopic surgeries.Timepoint: metric units by visual analog scale for the first 24 hours	—

Secondary

Measure	Time frame
To study the requirement for rescue anti-emetic medications Timepoint: number of persons requiring anti emetics in metric terms for 24 hours in the post operative period	—

Countries

India

Contacts

Public ContactNidhi Srivastava

Indira Gandhi Government General Hospital

drnidhi33@gmail.com8489901978

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026