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Effects of Periodontal Therapy on Various Clinical Outcome in Patients with COPD & Severe Chronic Periodontitis

Effects of Periodontal Therapy on Biomarker Levels of TNF-α, hsCRP & IL-1β and Clinical Outcome in Patients with COPD & Severe Chronic Periodontitis

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/07/054960
Enrollment
60
Registered
2023-07-07
Start date
Unknown
Completion date
Unknown
Last updated
2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J449- Chronic obstructive pulmonary disease, unspecified

Interventions

Intervention1: Comparison of various parameters following periodontal therapy in COPD patients: The proposed study will evaluate the periodontal status and effects of periodontal therapy on clinical o

Sponsors

Self
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: o Patients of either sex above 40 years of age o Patients having >= 20 natural teeth o Patients with CAL 5mm o Full Mouth Bleeding score (FMBS)30%.

Exclusion criteria

Exclusion criteria: o Patients with history of periodontal treatment in last 6 months. o Patients under long-term antibiotics known to influence periodontal health. o Patients with chronic systemic inflammatory disease. o Patients with worsening of respiratory symptoms and expected survival of less than 2 years. o Inability to provide information or to cooperate with the dental examinations. o Patients with any co-morbidity affecting periodontal health. o Pregnant and lactating patients. o Patients unable to perform lung function test.

Design outcomes

Primary

MeasureTime frame
The expected outcomes after periodontal therapy in COPD patients are as following: oDecrease in frequency of acute exacerbation and number of hospitalization in COPD patients after periodontal therapy. oSignificant change in biomarker levels of TNF-α, hsCRP & IL-1β in COPD patients after periodontal therapy. oImproved quality of life after periodontal therapy. oImproved lung functions after periodontal therapy. Timepoint: The outcomes will be assessed at the end of first year

Secondary

MeasureTime frame
NilTimepoint: Nil

Countries

India

Contacts

Public ContactDr Deepmala Maurya

Maulana Azad institute of dental sciences New Delhi

deepmalamaids@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026