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The altered gene expression profiles of leprosy causing bacteria and the human host in patients with chronic and recurrent type 2 lepra reaction.

The host-bacilli transcriptional profile in patients with chronic and recurrent erythema nodosum leprosum - NIl

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2023/07/054861
Enrollment
25
Registered
2023-07-06
Start date
Unknown
Completion date
Unknown
Last updated
2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: A305- Lepromatous leprosy

Interventions

Intervention1: Nil: Nil Control Intervention1: Nil: Nil

Sponsors

Indian Association of Dermatologists, Venereologists & Leprologists (IADVL)
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All the cases of severe chronic and recurrent erythema nodosum leprosum, defined as ENLIST ENL Severity Scale (EESS) score =9, who will present to the OPD of the Dermatology department

Exclusion criteria

Exclusion criteria: i. Patients with known immunodeficiency or on immunosuppressive drugs within last month ii. Patients not willing to give consent iii. Pregnancy and lactation

Design outcomes

Primary

MeasureTime frame
To characterize the transcriptome profiles of host-bacilli in patients with chronic & recurrent erythema nodosum leprosumTimepoint: April 2025—

Secondary

MeasureTime frame
To observe the association between antimicrobial resistance & the presence of chronic & recurrent erythema nodosum leprosumTimepoint: April 2025—

Countries

India

Contacts

Public ContactDr Biswanath Behera

AIIMS Bhubaneswar

biswanathbehera61@gmail.com7978351200

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026