To know the efficacy of topical carboxymethylcellulose (0.5%), cyclosporine (0.03%) & chloroquine (0.03% ) in cases of dry eye disease

Efficacy of topical carboxymethylcellulose (0.5%) , cyclosporine A (0.05%) and chloroquine (0.03% ) in cases of moderate to severe dry eye disease - nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/07/054823

Enrollment

180

Registered

2023-07-06

Start date

Unknown

Completion date

Unknown

Last updated

2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H048- Other disorders of lacrimal system

Interventions

Intervention1: GROUP CMC : Group 1 will receive topical eyedrops Carboxymethylcellulose(0.5%) four times daily. Control Intervention1: GROUP 1, 2 ,3: Group 1 will receive eyedrops Carboxymethylcellulo

Eligibility

Inclusion criteria

Inclusion criteria: Cases of moderate to severe dry eye disease with best corrected visual acuity of more than or equal to 660 attending the outpatient department of RIO, IMS, BHU. Cases giving written consent to participate in the study

Exclusion criteria

Exclusion criteria: sensitivity to eyedrops ocular infection, ocular injury or trauma or past ocular surgery. uncontrolled systemic disease contact lens wearer. chronic alcoholics, pregnant or lactating women. already received treatment for dry eye disease

Design outcomes

Primary

Measure	Time frame
•Slit lamp biomicroscopy •Schirmer’s test using 41 no Whatmann filter paper strips •Tear film break up time using fluorescein staininG •Ocular Surface disease index (OSDI) •Fluorescein stain score Timepoint: DAY 0 WEEK 1 WEEK 4 WEEK 8 WEEK 12	—

Secondary

Measure	Time frame
VISUAL ACUITY BEST CORRECTED VISUAL ACUITY SLIT LAMP BIOMICROSCOPYTimepoint: DAY 0 WEEK 1 WEEK 4 WEEK 8 WEEK 12	—

Countries

India

Contacts

Public ContactDr Samvida Parihar

Banaras Hindu University

samvidaparihar19@gmail.com7232917529

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026