Comparison of ropivacaine alone vs ropivacaine with clonidine in spinal anesthesia for lower limb surgeries

A randomised control trial in spinal anesthesia with 0.75 % hyperbaric ropivacaine alone versus 0.75 % hyperbaric ropivacaine with clonidine for lower limb surgeries - SAB

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/07/054774

Enrollment

100

Registered

2023-07-05

Start date

Unknown

Completion date

Unknown

Last updated

2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 4- Measurement and Monitoring

Interventions

Intervention1: CLONIDINE: To compare the efficacy of Clonidine as adjuvant to 0.75% Hyperbaric Ropivacaine in spinal anesthesia in lower limb surgeries while maintaining the hemodynamic stability in p

Eligibility

Inclusion criteria

Inclusion criteria: 1.All patients willing for study 2.Patients who are conscious and oriented 3.All patients undergoing lower limb procedures 4.All patients under ASA1,ASA 2,ASA 3 categories 5.All patients undergoing only spinal anaesthesia

Exclusion criteria

Exclusion criteria: 1.Patients who refuse for spinal anaesthesia 2.Pregnant patients 3.Patients with spinal birth defects, hematological conditions, coagulopathies 4.Psychiatric patients 5.Unconscious ,not oriented ,comatosed patients

Design outcomes

Primary

Measure	Time frame
1.Monitoring hemodynamic and respiratory parameters such as blood pressure , pulse rate , oxygen saturation in pulse oximetry ,mean arterial pressure. 2.Onset of sensory and motor blockade. 3.Duration of sensory and motor blockade.Timepoint: 1.Heart rate and Mean arterial pressure at baseline, 3mts, 5mts,15mts, 30mts, 45mts, 1hr and every 30 mts till end of surgery. 2.Time taken from time of spinal injection to the loss of pin prick sensation at the level of the hip and time taken from time of spinal injection to the inability to lift the leg. 3.Time taken from time of spinal injection to the time when patient complains of pain and from the time of spinal injection to the ability to lift the leg.	—

Measure

Time frame

1.Monitoring hemodynamic and respiratory parameters such as blood pressure , pulse rate , oxygen saturation in pulse oximetry ,mean arterial pressure. 2.Onset of sensory and motor blockade. 3.Duration of sensory and motor blockade.Timepoint: 1.Heart rate and Mean arterial pressure at baseline, 3mts, 5mts,15mts, 30mts, 45mts, 1hr and every 30 mts till end of surgery. 2.Time taken from time of spinal injection to the loss of pin prick sensation at the level of the hip and time taken from time of spinal injection to the inability to lift the leg. 3.Time taken from time of spinal injection to the time when patient complains of pain and from the time of spinal injection to the ability to lift the leg.

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Secondary

Measure	Time frame
Which drug - With or without adjuvant-is more hemodynamically stable & early post operative recoveryTimepoint: 1.Heart rate & Mean arterial pressure at baseline, 3mts, 5mts,15mts, 30mts, 45mts, 1hr & every 30 mts till end of surgery. 2.Time taken from time of spinal injection to the loss of pin prick sensation at the level of the hip & time taken from time of spinal injection to the inability to lift the leg. 3.Time taken from time of spinal injection to the time when patient complains of pain & from the time of spinal injection to the ability to lift the leg.	—

Measure

Time frame

Which drug - With or without adjuvant-is more hemodynamically stable & early post operative recoveryTimepoint: 1.Heart rate & Mean arterial pressure at baseline, 3mts, 5mts,15mts, 30mts, 45mts, 1hr & every 30 mts till end of surgery. 2.Time taken from time of spinal injection to the loss of pin prick sensation at the level of the hip & time taken from time of spinal injection to the inability to lift the leg. 3.Time taken from time of spinal injection to the time when patient complains of pain & from the time of spinal injection to the ability to lift the leg.

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Countries

India

Contacts

Public ContactDR RAVI

ACS MEDICAL COLLEGE AND HOSPITAL

ravibala181@gmail.com9840123852

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026