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Modulation of neural circuitry in Obsessive Compulsive Disorder with Transcranial Direct Current Stimulation

Comparison of Anodal and cathodal High Definition Transcranial Direct Current Stimulation(HD-tDCS) over the pre-supplementary motor area in Obsessive Compulsive Disorder-A double-blind, placebo controlled, randomized clinical trial[PROBE study] - PROBE study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/07/054676
Enrollment
45
Registered
2023-07-03
Start date
Unknown
Completion date
Unknown
Last updated
2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F422- Mixed obsessional thoughts and acts

Interventions

Intervention1: High Definition-Transcranial Direct Current Stimulation: This is a new technique of tDCS in which smaller and specially designed electrodes are used. In this 4X1 ring configuration mont

Sponsors

Shalini S Naik
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Participant with a diagnosis of OCD by DSM-5 TR. 2.Clinically significant OCD symptoms(YBOCS >16). 3.On anti-obsessional agents for at least 8 weeks prior to the intervention period. 4.No change in medication in the past 2 weeks (except for benzodiazepine), and not planned to undergo the same. 5.Not engaged in CBT/ERP in the past 2 weeks, and not planned to undergo the same during the 5-day intervention period. 6.Providing written informed consent.

Exclusion criteria

Exclusion criteria: 1.Patients with primary psychotic or primary mood disorders. 2.Patients with a neurological disorder like multiple sclerosis, stroke, epilepsy, or encephalopathy due to any cause. 3.Patients with any intracranial metallic and electric implants. 4.Patients with comorbid organic brain syndrome and intellectual disability. 5.Patients with OCD associated underlying organic illness

Design outcomes

Primary

MeasureTime frame
To compare the relative efficacy in reduction of Y-BOCS score in Cathodal Vs Anodal Vs Sham HD-tDCS of pre-SMA in patient with OCDTimepoint: Pre Intervention(before 1st session of HD-tDCS) Post Intervention(After 10th session of HD-tDCS)

Secondary

MeasureTime frame
To compare relative efficacy of cathodal vs anodal vs sham Hd tDCS of pre-SMA in patients with OCDTimepoint: Pre intervention and post intervention

Countries

India

Contacts

Public ContactHarshad Wankhede

Post Graduate Institute of Medical Education and Research

drshalini.anji@gmail.com9886313489

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026