Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Propofol: Dose: 25 - 100 mcg/kg/min
Route: intravenous
Frequency: entire duration of surgery( approximately 2-3 hours)
Control Intervention1: Sevoflurane: Dose : 1- 2% v/v in gaseous
Sponsors
Postgraduate Institute of Medical Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: Ruptured aneurysm posted for Surgical Clipping WFNS grade 1,2,3 Anterior circulation aneurysm
Exclusion criteria
Exclusion criteria: Postictal day 4 or more Postoperative neurological deterioration due to surgical or systemic causes Hydrocephalus
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the incidence of delayed cerebral ischemia in patients undergoing clipping of aneurysm surgery under general anesthesia with sevoflurane when compared to propofol.Timepoint: starting after the surgery till the discharge from hospital | — |
Secondary
| Measure | Time frame |
|---|---|
| Estimation of CSF eNOS levelsTimepoint: intraoperative ( during aneurysm Clipping surgery);Neurological outcome at 3 months post surgery(GOSE, MRS score)Timepoint: 1 months after surgery, 3 months after surgery;Neurological outcome at discharge ( MRS score)Timepoint: at discharge | — |
Countries
India
Contacts
Public ContactDr Hemant Bhagat
Postgraduate institute of medical education and research, chandigarh
Outcome results
None listed