Health Condition 1: G998- Other specified disorders of nervous system in diseases classified elsewhere
Conditions
Interventions
Control Intervention1: injection Fosphenytoin 4-6 mg/kg intravenous: additional dose of injection Fosphenytoin 4-6 mg/kg intravenous intraoperatively alongwith regular dosed received pre-operatively a
Sponsors
Mahatma Gandhi medical college and hospital
Eligibility
Inclusion criteria
Inclusion criteria: ASA physical status I, II, III Aged 18-60 years scheduled for supratentorial craniotomy for tumor resection patients who were receiving single anticonvulsant medication for more than one-week duration
Exclusion criteria
Exclusion criteria: Patient refusal History of allergy to the study drug Impaired renal/hepatic function. Severe left ventricular dysfunction, Seizures within one week prior to surgery despite the use of antiepileptic drug, patients who were on two anticonvulsants, Patients with GCS 4 cm associated with midline shift of >5 mm, surgery lasting longer than 5 hours with >30% blood volume loss
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the effect of prophylactic additional anticonvulsants on time to recovery from anaesthesia.Timepoint: Time taken from stopping the Isoflurane to extubation, eye-opening, to obey command & to get oriented will be taken as extubation time, eye-opening time, time to obey the command, time to orientation | — |
Secondary
| Measure | Time frame |
|---|---|
| â?¢Hemodynamic changes â?¢Depth of Anaesthesia â?¢Incidence of post operative seizure in first 48hours â?¢Plasma anticonvulsant levels Timepoint: heart rate, mean arterial blood pressure at 5,10,20,30,60,90,120,150,180,210 minutes | — |
Countries
India
Contacts
Public ContactDr Sunita Sharma
Mahatma Gandhi Medical college and hospital, Jaipur
Outcome results
None listed