Addition of Hyluronidase in Supraclavicular block, to hasten the onset of block in upper limbs surgeries

"Effect of Addition of Hyaluronidase As An Adjuvant To Bupivacaine In Supraclavicular Brachial Plexus Block ;A prospective randomized controlled study

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/06/054470

Enrollment

Registered

2023-06-27

Start date

Unknown

Completion date

Unknown

Last updated

2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: V235- Motorcycle passenger injured in collision with car, pick-up truck or van in traffic accident Health Condition 3: V295- Motorcycle passenger injured in collision with other and unspecified motor vehicles in traffic accident

Interventions

Intervention1: GROUP-H:USG guided supraclavicular brachial plexus block with 16ml 0.5%bupivacaine with 1500 units of hyaluronic acid diluted with 2ml NS.: USG guided supraclavicular brachial plexus

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA I and II patients of either sex. 2.Patients aged between 18 to 60 years 3. Patients undergoing elective upper limb forearm and hand surgeries.

Exclusion criteria

Exclusion criteria: 1.Patients with known hypersensitivity to local anesthetic drugs. 2.Bleeding disorders or on anticoagulants, uncontrolled diabetes mellitus, renal and liver diseases and severe respiratory disease 3.Neurological deficit involving the brachial plexus 4.Pregnant and lactating women, patients with epilepsy and mentally unstable patients. 5.Local site infection, peripheral vascular disease. 6.Patientâ??s refusal.

Design outcomes

Primary

Measure	Time frame
To compare the time of onset of motor block with addition of hyaluronidase with bupivacaine and bupivacaine aloneTimepoint: to note intraoperative vitals at 0,15,30,45,60,75,90,105,120,135, 165,180 minutes	—

Secondary

Measure	Time frame
To compare the duration of block motor and sensoryTimepoint: to note vas at 0,2,4,6,10,12,12,18,24 hours	—

Countries

India

Contacts

Public ContactDrJyoti Petkar

Rajarajeswari Medical College and Hospital

jokiran2009@gmail.com7726899533

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026