Health Condition 1: K742- Hepatic fibrosis with hepatic sclerosis
Conditions
Interventions
Intervention1: Dapagliflozin: To be given in 10 mg OD oral route daily once only for at least 6 months
Control Intervention1: Insulin with or without metformin: Insulin to be given as long acting or s
Sponsors
Pt BD Sharma Institute of Medical Science, Rohtak
Eligibility
Inclusion criteria
Inclusion criteria: All Patients with liver cirrhosis having age 18years to 70years with Diabetes Mellitus requiring drug treatment. Patients who are willing to participate
Exclusion criteria
Exclusion criteria: Age 70years. Cerebrovascular disorder, any neurological disorder including dementia/Alzheimerâ??s etc.Pregnancy.Chronic kidney disease . Any malignancy excluding Hepatocellular Carcinoma .Patient who refused to give consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Control of Diabetes as defined by Fasting blood sugar 80 to 130 mg/dl and 2hr post prandial blood sugar below 180 mg/dl at 1, 3 and 6 monthTimepoint: 1st ,3rd and 6th month | — |
Secondary
| Measure | Time frame |
|---|---|
| Episodes of hypoglycemia, Compliance to treatment, Status of Ascites, episodes of spontaneous bacterial peritonitis (SBP)/ Upper Gastrointestinal bleeding/ jaundice/ Hepatorenal Syndrome(HRS) , Change in ChildTurcottePugh(CTP) score and MELD 3.0 score from baseline at 3 and 6 month.Timepoint: 3rd and 6th month | — |
Countries
India
Contacts
Public ContactDr Tarana Gupta
Pt.BDS institute of Medical Science,Rohtak
Outcome results
None listed