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A cohort study to study fever in the community with focus on Dengue and Chikungunya in India

Establishment of surveillance system in a rural population cohort for describing epidemiology of Dengue infection towards setting up of field-based clinical trial site in Model rural health research unit in Tirunelveli, Tamil Nadu

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2023/06/054453
Enrollment
750
Registered
2023-06-26
Start date
Unknown
Completion date
Unknown
Last updated
2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R00-R99- Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified

Interventions

None listed

Sponsors

National Biopharma Mission NBM Biotechnology Industry Research Assistance Council BIRAC
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Survey will be carried out in individuals above 2 years of age and individuals currently residing and likely to stay till the end of the study (1 year) in the study area will be considered eligible for inclusion

Exclusion criteria

Exclusion criteria: Consent Refusal

Design outcomes

Primary

MeasureTime frame
1. Incidence rate of acute febrile illness episode during 12 months of follow up 2. b.Incidence rate of symptomatic laboratory confirmed Dengue infection episodes during 12 months of follow up 3. c.Incidence of Sero positivity based on IgG, IgM and neutralizing antibodies at 12 months (Sero Negative for IgG, IgM or Neutralizing antibodies at baseline at enrolment)Timepoint: 12 months

Secondary

MeasureTime frame
1. Incidence rate of symptomatic laboratory-confirmed Chikungunya infection episodes during 12 months of follow up 2. Determine etiology of AFI due to other common causes of AFI (based on rapid diagnostic or ELISA tests) a. Malaria b. Scrub typhus c. Leptospirosis d. Typhoid 3. Describe proportion of symptomatic versus asymptomatic or subclinical infections of dengue and chikungunya based on data obtained from primary objectives. 4. Identify and describe circulating serotypes of dengue, chikungunya in general population 5. To assess spatiotemporal trend of Dengue and Chikungunya infection 6. Determine the durability of IgG, IgM and Neutralizing antibodies in symptomatic individuals tested n positive for Dengue and Chikungunya infection. 7. Estimate the economic burden of dengue and chikungunya fevers based on information about: a. Patients with severe illness requiring hospitalization and / or ICU care b. Patients managed on out-patient basis. Timepoint: 12 months

Countries

India

Contacts

Public ContactDr R Prabhu

ICMR National Institute of Epidemiology Chennai

driven.nie@gmail.com8072479674

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026