Health Condition 1: K740- Hepatic fibrosis
Conditions
Interventions
Intervention1: Proton pump inhibitor (PPI) after achieving hemostasis by EVL of bleeding esophageal varices: After achieving hemostasis by EVL for bleeding esophageal varices, patients in PPI group wo
Sponsors
Post Graduate Institute of Medical Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: Diagnosed cases of liver cirrhosis presenting with decompensation in the form of first episode of variceal bleed
Exclusion criteria
Exclusion criteria: 1-Refractory bleed requiring TIPSS or emergency surgery apart from EVL 2-Upper GI bleed due to acid peptic disease/GERD 3-Hepatocellular carcinoma 4-upper GI Bleed due to malignant tutors go the GI tract 5-Hemodynamic instability requiring vasopressor support 6-Hepatic encephalopathy grade III or above 7-History of surgery of oesophagus, stomach or liver 8- Renal failure with creatinine >2mg/dl 9-Presence of gastric varices as source of upper GI bleed 10-Pregnancy/breastfeeding 11-PPI allergy 12-Mising informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the rate of recurrent bleeding between PPI versus no PPI groups after EVL in liver cirrhosis patients with acute varicella bleedTimepoint: From baseline till 12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1-Compare mortality between the 2 groups 2-Compare the size & number of post EVL ulcers at 2 weeks after first EVL session 3- Compare chest pain between 2 group at 2 week and 12 weeks 4-Compare rate of dysphagia between the 2 groupsTimepoint: At 3 months | — |
Countries
India
Contacts
Public ContactHarshal Mandavdhare
Post Graduate Institute of Medical Education and Research
Outcome results
None listed