Comparative evaluation of 3% warm sodium hypochlorite & 3% sodium hypochlorite during root canal irrigation on post-operative pain

Impact Of Cryotreated And Warm Sodium Hypochlorite On Post-Operative Pain In Patients With Symptomatic Irreversible Pulpitis: A Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/06/054384

Enrollment

Registered

2023-06-23

Start date

Unknown

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: Cryotreated sodium hypochlorite: Canals will be irrigated with 20ml of 3% NaOCl at 2 ? C using 30-G needle placed 2mm short of the working length for 5 minutes Intervention2: Warm sodiu

Eligibility

Inclusion criteria

Inclusion criteria: 1. Mandibular first or second molars with symptomatic irreversible pulpitis. 2. Mandibular molars with mature apices 3. Patients not taking any analgesics for 6 hours preoperatively 4. No history of endodontic treatment 5. The ‘mild to maximum’ pre-operative pain on HP-VAS will be taken

Exclusion criteria

Exclusion criteria: 1. Teeth with periapical radiolucency 2. Teeth with calcified canals 3. Pregnant or lactating patients 4. Patients with history of allergy to any of the components of local anaesthetic solution 5. Teeth with internal root resorption

Design outcomes

Primary

Measure	Time frame
To evaluate the effect of final irrigation of root canals with cryotreated 3 percent sodium hypochlorite solution at 2 degrees celsius, room temperature 3 percent sodium hypochlorite solution at 25 degrees celsius & heated 3 percent sodium hypochlorite solution at 60 degrees celsius on postoperative pain level.Timepoint: Postoperative pain will be evaluated at 6, 24, 48 & 72 hours	—

Secondary

Measure	Time frame
To compare the efficacy of 3 percent sodium hypochlorite, warm hypochlorite & cryotreated hypochlorite on post operative painTimepoint: Postoperative pain will be evaluated at 6, 24, 48 & 72 hours	—

Countries

India

Contacts

Public ContactSerena Lalfakawmi

Manav Rachna Dental College

principal.mrdc@mrei.ac.in9958120033

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026