To compare the incidence of hypotension and bradycardia by using two sympathomimetic drugs ,phenylephrine and noradrenaline among patients undergoing cesarean section under spinal anesthetia

Comparison of prophylactic infusion of norepinephrine and phenylephrine for the maintenance of hemodynamics following subarachnoid block during cesarean section: an interventional double blind randomised trial - No

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/06/054376

Enrollment

128

Registered

2023-06-23

Start date

Unknown

Completion date

Unknown

Last updated

2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O295- Other complications of spinal andepidural anesthesia during pregnancy

Interventions

Intervention1: Norepinephrine: Prophylactic infusion of Norepinephrine at 2.5 mcg/hr from the time of incision to till delivery of the baby Control Intervention1: Phenylephrine: Prophylactic infusion

Eligibility

Inclusion criteria

Inclusion criteria: 1)Parturients with uncomplicated term singleton pregnancy undergoing elective cesarean delivery and belonging to American Society of Anaesthesiologists classification 2 2) Age 18 to 35 yrs 3) Parturients giving informed written and valid consent

Exclusion criteria

Exclusion criteria: 1) parturients having hypertensive disorders of pregnancy, diabetes milletus, cardiac, cerebrovascular, renal disorders, oligohydramnios, IUGR. 2) parturients having hypersensitivity to any of the study drugs 3) parturients with known contraindications to spinal anaesthesia

Design outcomes

Primary

Measure	Time frame
To compare the incidence of bradycardia among phenylephrine and norepinephrine groupsTimepoint: Measuring HR every 1 minute from onset of spinal action till delivery of baby	—

Secondary

Measure	Time frame
Incidence of hypotensive episodes, maternal systolic and diastolic blood pressure, MAP,number of boluses of vasopressors required, reactive hypertension.Timepoint: Measuring, BP and MAP every one minute from onset of spinal anaesthesia to delivery of the baby	—

Countries

India

Contacts

Public ContactDr Sushma KS

Karnataka Institute of medical sciences,

dr.sushsam@gmail.com9844310403

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026