Effect of rTMS in addition to standard treatment on craving and metabolites level at DLPFC through magnetic resonance spectroscopy among patients using cannabis and opioid concurrently in dependence pattern

Effect of adjunctive rTMS on cue related craving and its relationship with glutamate and myoinositol levels at DLPFC among patients with comorbid cannabis and opioid dependence syndrome-an H1 MRS based comparative study - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/06/054352

Enrollment

Registered

2023-06-23

Start date

Unknown

Completion date

Unknown

Last updated

2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F122- Cannabis dependence Health Condition 2: F112- Opioid dependence

Interventions

Intervention1: Transcranial magnetic stimulation: Stimulation-8 continuous sessions will be given to first group-comorbid cannabis and opioid dependence syndrome Control Intervention1: Transcranial ma

Eligibility

Inclusion criteria

Inclusion criteria: Ready to give informed consent Clinical Opiate Withdrawal Scale Cannabis withdrawal Scale Started on Naltrexone 50mg/day

Exclusion criteria

Exclusion criteria: Any other comorbid substance use excluding caffeine and nicotine Any comorbid psychiatric disorders Any contraindication for undergoing rTMS and MRS Not willing to give informed consent

Design outcomes

Primary

Measure	Time frame
Change in level of glutamate & myoinositol at DLPFC after Transcranial magnetic stimulationTimepoint: Baseline and after completion of TMS i.e. after 1 week	—

Secondary

Measure	Time frame
OCDUS(Obcessive compulsive drug use scale),MCQ(Marijuana craving questionnaire) scoresTimepoint: Baseline & after intervention is over	—

Countries

India

Contacts

Public ContactDr S K Munda

Central institute of psychiatry

drsanjaymunda@gmail.com8797641082

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026