FindTrial
Sign In

A study to assess the hair changes post induction chemotherapy in pediatric patients with acute lymphoblastic leukemia and to study the effects of scalp cooling on ameliorating these changes

A prospective study to assess the hair changes post induction chemotherapy in pediatric patients with acute lymphoblastic leukemia and to study the effects of scalp cooling on ameliorating these changes

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/06/054343
Enrollment
20
Registered
2023-06-22
Start date
Unknown
Completion date
Unknown
Last updated
2024-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C910- Acute lymphoblastic leukemia [ALL]

Interventions

Intervention1: Scalp cooling: scalp cooling cap will be applied 5 mins mins prior, during and after IV induction chemotherapy. Control Intervention1: No intervention will be done in these patients: Pa

Sponsors

Dr Aditya Kumar Gupta
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: IR(Intermediate) and HR(High risk) ALL and undergoing induction chemotherapy.

Exclusion criteria

Exclusion criteria: Child receiving any therapy (topical or oral) for the alopecia. Child unwilling to undergo scalp cooling. Child with SAM Child with poor hair hygiene Child with suspected autoimmune disease. Relapsed children or who have got any previous chemotherapy (apart from steroids).

Design outcomes

Primary

MeasureTime frame
1.Clinical 1.Visual inspection byCTCAE GARDING 2.Trichoscopic pattern - Black dots - Broken hairs - Exclamation marks - Flame hairs - Pohl pinkus - Circle hair - pigtails 3. Trichogram characteristic - Dystrophic anagen hairs - Dysplatic anagen hairs 4.Radiological (Ultrasonography) S.USG Parameter - Dermal thickness - Scalp hair follicle depth - Scalp hair follicle transverse diameter(width) - Hair shaft thickness 5. 4.Anatomical (ultrastructure- using SEM) Shaft Root of hair Timepoint: pre and post induction chemotherapy in control arm—

Secondary

MeasureTime frame
1. Clinical 1.Visual inspection by CTCAE GARDING 2.Trichoscopic pattern - Black dots - Broken hairs - Exclamation marks - Flame hairs - Pohl pinkus - Circle hair - pigtails 3. Trichogram characteristic - Dystrophic anagen hairs - Dysplatic anagen hairs 4.Radiological (Ultrasonography) S.USG Parameter - Dermal thickness - Scalp hair follicle depth - Scalp hair follicle transverse diameter(width) - Hair shaft thickness 5. 4. Anatomical (ultrastructure- using SEM) Shaft Root of hair Timepoint: pre and post induction chemotherapy in intervention and control arm—

Countries

India

Contacts

Public ContactRahul Kumar

AIIMS, New Delhi

adivick@gmail.com7838379837

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026