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Effect of brief episodes of decreased blood supply and restoring the flow of blood ,applied in remote tissue on postoperative kidney function and heart biomarkers in adult patients undergoing valvular heart surgery

Effect of remote ischemic preconditioning on postoperative renal function and cardiac biomarkers in adult patients undergoing valvular heart surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/06/054289
Enrollment
80
Registered
2023-06-21
Start date
Unknown
Completion date
Unknown
Last updated
2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I083- Combined rheumatic disorders of mitral, aortic and tricuspid valves Health Condition 2: I089- Rheumatic multiple valve disease,unspecified

Interventions

Intervention1: Remote ischemic preconditioning done: After induction of anaesthesia, patients in study group will receive 3 cycles of blood pressure cuff inflation above 100mmHG of systolic BP on righ

Sponsors

Vardhman Mahavir Medical College and Safdarjung Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adult patients in age 18-65 years, either gender posted for valvular heart surgery on cardiopulmonary bypass.

Exclusion criteria

Exclusion criteria: 1)Left ventricular ejection fraction 2)Comorbidities like cardiomyopathy, cerebrovascular disease 3)Peripheral vascular disease 4)Patients with chronic kidney disease

Design outcomes

Primary

MeasureTime frame
To evaluate the effect of remote ischemic preconditioning on 1)Renal function by measuring blood urea nitrogen, serum creatinine and creatinine clearance 2)Myocardial function by measuring creatinine phosphokinase(total), CPK-MB and Troponin ITimepoint: 1) Pre op 2)End of surgery 3)12 hours after surgery 4)24 hours after surgery 5)48 hours after surgery 6)72 hours after surgery—

Secondary

MeasureTime frame
To evaluate the effect of remote ischemic preconditioning on a) Post operative Atrial Fibrillation (AF) b)Respiratory function by means of PaO 2 / FiO 2 Ratio c)Length of Intensive Care Unit stayTimepoint: At the end of surgery, 12, 24, 48 and 72 hours post-surgery.—

Countries

India

Contacts

Public ContactDR SANJANA S

Safdarjung Hospital and Vardhman Mahavir Medical College

drmeenakshi86@yahoo.com9899689829

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026