A clinical trial to study the effect of auditory training in improving cognition in individuals with mild cognitive impairment.

Effect of Auditory Training on Working Memory & Attention in Individuals with Mild Cognitive Impairment - A Randomized Controlled Trial - ATCOG

Status

Recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/06/054277

Enrollment

Registered

2023-06-21

Start date

Unknown

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G311- Senile degeneration of brain, notelsewhere classified

Interventions

Intervention1: Auditory Training: The auditory training will have tasks tapping the central auditory processing. Tasks will be specifically focusing on temporal processing abilities like temporal reso

Eligibility

Inclusion criteria

Inclusion criteria: Phase I & II: Study Group Patients with a diagnosis of Mild Cognitive Impairment as per the National Institute of Aging Alzheimers Association NIA AA MoCA scores 19 to 25 Audiometric thresholds less than 40 dBHL in 250 500 and 1000 Hz Participants with normal middle ear function which will be confirmed using Interacoustics middle ear analyzer Education level greater than 8th grade Phase I- Control Group Age and hearing-matched controls MoCA scores greater than 25 Educational level greater than 8th grade.

Exclusion criteria

Exclusion criteria: Both Groups: Patients undergoing cognitive or behavioural interventions to improve cognition Presence or history of other neurological disorders like stroke epilepsy brain injury or tumor based on their medical history Presence of psychological illness based on Patient Health Questionnaire PHQ 9

Design outcomes

Primary

Measure	Time frame
Cognition: i.The ACE- III- Total scores ii.Mental rotation test: Reaction time in milliseconds & response accuracy iii.Digit span test: Length of longest digits recalled- forward & backward iv.Trail Making test: Response time in seconds v.Attention Network Test: Total scores Timepoint: 4-time points- Baseline, four weeks after treatment, Post-treatment (8 weeks), One-month follow-up post-treatment.	—

Measure

Time frame

Cognition: i.The ACE- III- Total scores ii.Mental rotation test: Reaction time in milliseconds & response accuracy iii.Digit span test: Length of longest digits recalled- forward & backward iv.Trail Making test: Response time in seconds v.Attention Network Test: Total scores Timepoint: 4-time points- Baseline, four weeks after treatment, Post-treatment (8 weeks), One-month follow-up post-treatment.

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Secondary

Measure	Time frame
i.DDT- Right ear scores, left ear scores & total correct scores. ii.QuickSiN- SNR loss in dB iii.Gap detection threshold at all frequencies. iv.TFS-AF- Highest frequency as threshold. v.Frequency Modulation Difference Limen- Modulation rate (Hz) vi.Temporal Modulation Transfer Function- a graph of amplitude modulation as function of frequencyTimepoint: 4-time points- Baseline, four weeks after treatment, Post-treatment (8 weeks), One-month follow-up post-treatment.;Neurophysiological changes: EEG Connectivity measures (Phase Locking Value & Coherence)Timepoint: 2- time points, Baseline & post- treatment (8 weeks)	—

Measure

Time frame

i.DDT- Right ear scores, left ear scores & total correct scores. ii.QuickSiN- SNR loss in dB iii.Gap detection threshold at all frequencies. iv.TFS-AF- Highest frequency as threshold. v.Frequency Modulation Difference Limen- Modulation rate (Hz) vi.Temporal Modulation Transfer Function- a graph of amplitude modulation as function of frequencyTimepoint: 4-time points- Baseline, four weeks after treatment, Post-treatment (8 weeks), One-month follow-up post-treatment.;Neurophysiological changes: EEG Connectivity measures (Phase Locking Value & Coherence)Timepoint: 2- time points, Baseline & post- treatment (8 weeks)

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Countries

India

Contacts

Public ContactDr G Kanaka

Manipal Academy of Higher Education

g.kanaka@manipal.edu9845384136

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026