Health Condition 1: F332- Major depressive disorder, recurrent severe without psychotic features Health Condition 2: F330- Major depressive disorder, recurrent, mild Health Condition 3: F331- Major depressive disorder, recurrent, moderate Health Condition 4: F320- Major depressive disorder, singleepisode, mild Health Condition 5: F321- Major depressive disorder, singleepisode, moderate Health Condition 6: F322- Major depressive disorder, singleepisode, severe without psychotic features
Conditions
Interventions
Intervention1: ORAL KETAMINE (5O MG/ 1 ML VIAL): Dose of 1.5 mg /kg of ketamine will be given in 150ml of Paper boat juice ( apple flavour)
9 doses over 1 month
Control Intervention1: DISTILLED WATER:
Sponsors
Department of psychiatry
Eligibility
Inclusion criteria
Inclusion criteria: 1. All participants who have not responded adequately to therapeutic trials of 2 antidepressants of different classes given in adequate dose for 6 weeks. 2. Participants should be on stable medication of antidepressants for a period of at least 6 weeks. 3. Able to give informed consent.
Exclusion criteria
Exclusion criteria: 1. Participants who have taken Ketamine treatment (in any route) for depression before. 2. Participants having any known gastrointestinal issues or oral ulcers or diseases. 3. Pregnant participants. 4. Participants with age 5. Any other serious medical condition. 6. Any other associated psychiatric disorder.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessing Safety & efficacy of oral ketamine in treatment resistant depressionTimepoint: 10 VISITS 1st week 3 visits 2nd week 3 visits 3rd week 2 visits 4rth week 2 visits | — |
Secondary
| Measure | Time frame |
|---|---|
| Assess improvement in treatment resistant depression with active suicidal ideationTimepoint: 10 visits 1st week 3 visits 2nd week 3 visits 3rd week 2 visits 4rth week 2 visits | — |
Countries
India
Contacts
Public ContactDR Drashti Shah
GMERS Medical College and Hospital Gotri
Outcome results
None listed