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Improving Safety during Cancer Surgery: Investigating the Impact of Different Techniques of of Mechanical Ventilation on Blood Pressure Drops after Anesthesia - A Clinical Study

Effects of low normal versus conventional minute ventilation on the incidence of hypotension after induction of general anesthesia in adult patients for major cancer surgery - a randomized controlled study. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/06/054245
Enrollment
60
Registered
2023-06-21
Start date
Unknown
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Low normal minute ventilation: For the first three minutes after induction of general anesthesia, participants will be mechanically ventilated with low normal minute ventilation with ti

Sponsors

MPMMCC Tata Memorial Centre Varanasi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Consenting patients of 18 - 65 years of age, of ASA Physical Status 1 and 2, posted for major cancer surgeries under general anesthesia with controlled mechanical ventilation, with or without regional analgesia.

Exclusion criteria

Exclusion criteria: Pregnant women, patients below 18 years of age, or above 65 years age. Patients of ASA physical status 3, 4 and 5, or severe cardiovascular, respiratory, neurological, renal, hepatic, and coagulation disorders. Patients posted for emergency surgeries. Patients with fasting periods of more than 2 hours (continuing on clear fluids, after the last meal beyond 6 hours). Patients whose airways are secured by tracheostomy or awake tracheal intubation, or rapid sequence induction and intubation, and patients with anticipated difficult airway. Patients not willing to participate in the study. Patients in whom regional analgesia is planned to be administered prior to induction of general anesthesia.

Design outcomes

Primary

MeasureTime frame
Incidence of hypotension after induction of general anesthesiaTimepoint: Immediately after induction of general anesthesia, 1 minute, 2 minutes and 3 minutes after induction of general anesthesia—

Secondary

MeasureTime frame
End Tidal CO2 Oxygen saturation Heart rate Peak airway pressure Plateau airway pressure PEEP Total requirement (mg) of intravenous mephentermine injection to correct hypotension Any adverse effectsTimepoint: immediate preinduction, immediately after induction of general anesthesia, 1 minute, 2 minutes, 3 minutes after induction of general anesthesia—

Countries

India

Contacts

Public ContactJyotirmay Kirtania

MPMMCC Tata Memorial Centre Varanasi

jyotirmay@mpmmcc.tmc.gov.in05426917700

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026