Health Condition 1: Q89- Other congenital malformations, not elsewhere classified Health Condition 2: J189- Pneumonia, unspecified organism
Conditions
Interventions
Intervention1: Nil: Nil
Sponsors
Intramural Research Grant UCMS
Eligibility
Inclusion criteria
Inclusion criteria: Cases: children (2-59 months) with congenital heart disease confirmed by Echocardiography and presenting with pneumonia defined as per World Health Organisation Comparison group: children (2-59 months) (preferably age and sex matched) presenting with pneumonia without any known congenital heart defect.
Exclusion criteria
Exclusion criteria: -children with history of antibiotic intake in past 7 days -children with known immunodeficiency -children with chronic kidney and chronic liver disease -children with nasal deformity -children with structural lung malformation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nasopharyngeal carriage of S.pneumoniae in children with pneumonia with & without congenital heart diseaseTimepoint: At baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Serotype distribution & antibiotic resistance of S.pneumoniae. 2.Association of nasopharyngeal carriage of S.pneumoniae with pneumococcal vaccination. 3.Risk factors associated with carriage defined as age less than 2 years, malnutrition (weight for height less than -3SD), immunisation status, more than 1 siblings, siblings less than 6 years of age, overcrowding, smoker in family, h/o running nose within last 2 weeks, h/o pneumonia within last 1 year, h/o otitis media within last 1 year, h/o hospitalization within last 1 year. 4.Association between nasopharyngeal carriage of S.pneumoniae & S.aureus. 5.Nasopharyngeal & axillary carriage of S.aureus & in vitro antibiotic susceptibility patternTimepoint: At baseline | — |
Countries
India
Contacts
Public ContactDr Sumaira Khalil
University College of Medical Sciences
Outcome results
None listed