None listed
Conditions
Interventions
None listed
Sponsors
Central Council for Research in Ayurveda Sciences Ministry of Ayush New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: 1 Healthy volunteers 2 Willing to participate and give written informed consent 3 Physically independent, ambulatory volunteers 4 Right-handed 5 Willing to abstain from beverages such as coffee, tea, energy drinks or other such stimulants beginning 12 hours prior to fMRI 6 BMI of 17.5 to 30.5 kg/m2
Exclusion criteria
Exclusion criteria: 1 Presence of any illness or disease symptom as elicited by detailed clinical response, history and laboratory investigations 2 history of psychiatric disorders, as assessed by Mini international neuropsychiatric interview, or psycho-somatic disorders NasyaAnarha 3 history of psychiatric disorders, as assessed by Mini international neuropsychiatric interview, or psycho-somatic disorders 4 use of psychotropic medication known to interfere with the dopaminergic system or sedatives in the last six months 5 Family history of psychiatric diseases 6 Past or current abuse of psychoactive drugs, alcohol use and smoking 7 Contraindicated for MRI 8 Participants who have cognitive impairment 9 Women in menstrual or ovulatory phase 10 Intracranial abnormalities that can adversely affect the interpretation of the brain scans 11 Self-identifies as claustrophobic.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| â?¢To map brain neuro-physiological activity in response to Nasya through BOLD FMRI â?¢To explore brain hemodynamic response, such as alterations in blood flow, blood volume, and intravascular magnetic susceptibility, to Nasya Karma â?¢To study the effect of Marsa nasya procedure in apparently healthy volunteers in quality of life, cognitive, sleep and psychological domains. Timepoint: Time points for f-MRI - Before Treatment, within 15 minutes of nasya karma, 14th day Time points of questionnaire assessment - before treatment, 14th day, 30th day | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Effect of Marsa nasya in Montreal Cognitive Assessment Scale (MocA) in apparently healthy volunteers 2. Effect of Marsa nasya in Perceived Stress Scale in apparently healthy volunteers 3. Effect of Marsa nasya in Hamilton Anxiety Scale in apparently healthy volunteers 4. Effect of Marsa nasya in Pittsburg Sleep Quality Index in apparently healthy volunteers 5. Effect of Marsa nasya in SF36 Quality of Life Questionnaire in apparently healthy volunteers Timepoint: 0th day, 15th day, 30th day | — |
Countries
India
Contacts
Public ContactDrDevi R Nair
National Ayurveda Research Institute for Panchakarma Cheruthuruthy
Outcome results
None listed