Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Dexmedetomidine and ketamine: Comparative study
Intervention2: Group D: Dexmedetomidine infusion (0.5 mcg/kg/hr) to achieve target sedation.
Time points 2,4,6,8,12,24 hour till extubati
Sponsors
Dr Babaloo Kumar Singh
Eligibility
Inclusion criteria
Inclusion criteria: 1.Patients of ASA physical status 1 and 2 2.Patients between 18-60 years of age of either sex 3.Patients undergoing major abdominal surgery shifted to the ICU for elective ventilation.
Exclusion criteria
Exclusion criteria: 1.Patients who were pregnant or nursing; or had abnormal laboratory test results, significant psychiatric, neurological, cardiovascular, renal, or hepatic diseases. 2.Patients on Neuromuscular blocking agents
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of Dexmedetomidine with combination of ketamine & dexmedetomidine in analgesia for elective post-operative mechanical ventilation after major surgery Analgesia defined as BPS score 5.Timepoint: 1 year | — |
Secondary
| Measure | Time frame |
|---|---|
| Sedation score (till extubation) Time to Extubation Duration of ICU stay Side effect profiles Timepoint: 1 year | — |
Countries
India
Contacts
Public ContactDr Vinod kr Verma
Indira Gandhi institute of medical sciences
Outcome results
None listed