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Comparison between the effect of injecting 2% lignocaine inside the trachea or intravenous in reducing blood pressure and heart rate during visualisation of larynx and insertion of endotracheal tube inside the trachea

Comparison between transtracheal and intravenous 2% lignocaine in attenuating hemodynamic stress response following direct laryngoscopy and endotracheal intubation - NIL

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/06/054125
Enrollment
138
Registered
2023-06-19
Start date
Unknown
Completion date
Unknown
Last updated
2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R098- Other specified symptoms and signsinvolving the circulatory and respiratory systems

Interventions

Intervention1: Transtracheal injection of 2% preservative-free lignocaine 1.5 mg/kg: After induction of general anesthesia patients will receive preservative-free inj. lignocaine 2% (Loxicard® 2%, Neo

Sponsors

Dr Monotosh Pramanik
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: a)American Society of Anesthesiologists (ASA) I-II patients b)Aged between 18–60 years of both sexes c)Elective surgical cases under general anesthesia who will require direct laryngoscopy and endotracheal intubation d)Mallampati score I & II e)Single-attempt oral intubation

Exclusion criteria

Exclusion criteria: a)Patient refusal and patients who are unable to give valid consent b)Pregnant patients c)Known hypersensitivity to lignocaine d)Anticipated difficult airway e)Video laryngoscope-assisted intubation f) Patients with restricted neck mobility

Design outcomes

Primary

MeasureTime frame
To compare heart rate & blood pressure following direct laryngoscopy & endotracheal intubation in patients receiving 2 percent lignocaine, 1.5 mg/kg via transtracheal & intravenous route respectively.Timepoint: At induction of general anaesthesia, Heart rate and blood pressure will be noted just prior to intubation, immediately after intubation & then at 1, 3, & 5 minutes post intubation.

Secondary

MeasureTime frame
To note the incidence of postoperative sore throat in both groups.Timepoint: In the recovery room at arrival & after 24 hrs

Countries

India

Contacts

Public ContactMonotosh Pramanik

Mahamana Pandit Madan Mohan Malaviya Cancer Centre and Homi Bhabha Cancer Hospital

mpramanikforyou@gmail.com8413044039

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 5, 2026