Health Condition 1: F05- Delirium due to known physiological condition
Conditions
Interventions
Intervention1: Group 1:Ketamine 0.5mg/kg diluted to 3ml
Group 2: Normal saline 3ml
: After randomization and allocation, study drug and placebo will be prepared by an independent person and would be
Sponsors
Sir Ganga Ram Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Age>=65years ASA physical status I-III Both males & females Informed Consent
Exclusion criteria
Exclusion criteria: Patients previously diagnosed with dementia or stroke severe psychiatric or neurological diseases Patients with known uncompensated cardiovascular disease or hepato-renal insufficiency or uncontrolled endocrine disease Patients on an anti-depressant or anti-anxiety or anti-convulsant and anti-parkinsonism drugs Known case of severe visual or auditory dysfunction Known alcohol or substance abuse Preoperative cognitive impairment as assessed by 4A test >=4 is delirium Inability to perform neurocognitive tests
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative Delirium 4A Test â?¥ 4Timepoint: 1hr, 6hr after surgery and every day morning till discharge or postoperative day 7 | — |
Secondary
| Measure | Time frame |
|---|---|
| Hallucinations Timepoint: first 24 hrs. ;Intraoperative hemodynamic instabilityTimepoint: Intraoperatively;Postoperative nausea and vomiting as assessed by a 3-point Likert scale.Timepoint: During first 24 hrs;Postoperative pain assessed by numerical rating scale.Timepoint: During first 24hrs | — |
Countries
India
Contacts
Public ContactDr Neetu Jain
Sir Ganga Ram Hospital
Outcome results
None listed