Health Condition 1: N201- Calculus of ureter
Conditions
Interventions
Intervention1: Tamsulosin in Combination with Tadalafil: Tamsulosin 0.4mg
Tadalafil 10 mg
Control Intervention1: oral Silodosin 8mg once daily for 1 month: oral Silodosin 8mg once daily for 1 month
Sponsors
Sun Pharma
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients aged 18 years or above with distal ureteric calculi 2. Written informed consent.
Exclusion criteria
Exclusion criteria: 1.Patients with proximal ureteric calculi 2.Patients with multiple renal calculi 3.Patients with staghorn calculi 4.Patients with renal or ureteric anomalies 5.Pregnant women 6.Patients on calcium channel blockers or nitrate therapy for cardiac diseases 7.Patient’s with postural hypotension 8.Patients with a past history of floppy iris syndrome 9.Patient with fever more than 37.8ºC 10.Patients with a GFR =30 11.Patients with a history of ureteral surgery 12.Patients with known drug allergies 13.Patients in need of surgical or endoscopic intervention 14.Patients with uremic symptoms 15.Patients with diabetes, peptic ulcer or on concomitant treatment with b-blockers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To see the rate of stone expulsion after 1 month of therapy.Timepoint: To see the rate of stone expulsion after 1 month of therapy. | — |
Secondary
| Measure | Time frame |
|---|---|
| a)stone expulsion time b)number of pain episodes c)frequency of hospital visits Side effects of drugs usedTimepoint: 1 month | — |
Countries
India
Contacts
Public ContactPrasanna Ram
AIIMS, Bhubaneswar
Outcome results
None listed